pubmed-article:7676639 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:7676639 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
pubmed-article:7676639 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
pubmed-article:7676639 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
pubmed-article:7676639 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
pubmed-article:7676639 | lifeskim:mentions | umls-concept:C0205322 | lld:lifeskim |
pubmed-article:7676639 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
pubmed-article:7676639 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:7676639 | pubmed:dateCreated | 1995-10-13 | lld:pubmed |
pubmed-article:7676639 | pubmed:abstractText | The mechanism(s) by which infectious material is cleared by the host is an area of intensive study. This is especially so with the realization that persistent viral infection is a cause of chronic disease in humans and presents a major health problem. We have used the murine model of infection with lymphocytic choriomeningitis virus to evaluate immune clearance. Mice with a targeted disruption of the IFN-gamma gene mount effective cytotoxic T lymphocyte (CTL) responses after an acute viral challenge and clear virus. CD4+ T cells are not required but CD8+ T cells are mandatory. In contrast, CTL from mice with targeted disruption of the IFN-gamma gene are unable to clear virus from persistently infected mice. In addition to the requirement for IFN-gamma, CD4+ T cells are essential for maintaining a CD8(+)-mediated cure of persistent viral infection. | lld:pubmed |
pubmed-article:7676639 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7676639 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7676639 | pubmed:language | eng | lld:pubmed |
pubmed-article:7676639 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7676639 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:7676639 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7676639 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:7676639 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7676639 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:7676639 | pubmed:month | Sep | lld:pubmed |
pubmed-article:7676639 | pubmed:issn | 0042-6822 | lld:pubmed |
pubmed-article:7676639 | pubmed:author | pubmed-author:OldstoneM BMB | lld:pubmed |
pubmed-article:7676639 | pubmed:author | pubmed-author:TishonAA | lld:pubmed |
pubmed-article:7676639 | pubmed:author | pubmed-author:LewickiHH | lld:pubmed |
pubmed-article:7676639 | pubmed:author | pubmed-author:RallGG | lld:pubmed |
pubmed-article:7676639 | pubmed:author | pubmed-author:Von HerrathMM | lld:pubmed |
pubmed-article:7676639 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:7676639 | pubmed:day | 10 | lld:pubmed |
pubmed-article:7676639 | pubmed:volume | 212 | lld:pubmed |
pubmed-article:7676639 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:7676639 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:7676639 | pubmed:pagination | 244-50 | lld:pubmed |
pubmed-article:7676639 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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pubmed-article:7676639 | pubmed:meshHeading | pubmed-meshheading:7676639-... | lld:pubmed |
pubmed-article:7676639 | pubmed:year | 1995 | lld:pubmed |
pubmed-article:7676639 | pubmed:articleTitle | An essential role for type 1 interferon-gamma in terminating persistent viral infection. | lld:pubmed |
pubmed-article:7676639 | pubmed:affiliation | Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037, USA. | lld:pubmed |
pubmed-article:7676639 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:7676639 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:7676639 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
entrez-gene:15978 | entrezgene:pubmed | pubmed-article:7676639 | lld:entrezgene |
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