| pubmed-article:7675460 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7675460 | lifeskim:mentions | umls-concept:C0126732 | lld:lifeskim |
| pubmed-article:7675460 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:7675460 | lifeskim:mentions | umls-concept:C0699900 | lld:lifeskim |
| pubmed-article:7675460 | lifeskim:mentions | umls-concept:C0243125 | lld:lifeskim |
| pubmed-article:7675460 | lifeskim:mentions | umls-concept:C1749855 | lld:lifeskim |
| pubmed-article:7675460 | lifeskim:mentions | umls-concept:C1443643 | lld:lifeskim |
| pubmed-article:7675460 | lifeskim:mentions | umls-concept:C0039371 | lld:lifeskim |
| pubmed-article:7675460 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:7675460 | lifeskim:mentions | umls-concept:C0332206 | lld:lifeskim |
| pubmed-article:7675460 | lifeskim:mentions | umls-concept:C1705630 | lld:lifeskim |
| pubmed-article:7675460 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7675460 | pubmed:dateCreated | 1995-10-19 | lld:pubmed |
| pubmed-article:7675460 | pubmed:abstractText | The tax gene product of the human T-cell leukemia virus type I (HTLV-I) induces the nuclear expression and biological function of the NF-kappa B/Rel family of host transcription factors although the underlying mechanism remains unclear. In the present study, we demonstrate that Tax-mediated activation of NF-kappa B/Rel can be inhibited by a proteasome inhibitor, suggesting the involvement of proteolytic reactions in this Tax-specific activation pathway. Transient transfection and reporter gene assays have revealed that Tax overrides the inhibitory function of I kappa B alpha in both F9 embryonal cells and Jurkat T cells. Moreover, Tax-mediated inactivation of I kappa B alpha requires a 16 amino acid sequence element located at the N-terminal region (amino acid 21-36) of I kappa B alpha, which is also required for tumor necrosis factor alpha-induced degradation of this inhibitory protein. We further demonstrate that the proteasome inhibitor also blocks the degradation of I kappa B alpha observed in HTLV-I-infected T cells. Interestingly, inhibition of I kappa B alpha degradation in these cells led to the accumulation of a phosphorylated form of I kappa B alpha. Together, these studies suggest that Tax activation of NF-kappa B/Rel may involve induction of phosphorylation and subsequent proteasome-mediated degradation of the inhibitor I kappa B alpha. | lld:pubmed |
| pubmed-article:7675460 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7675460 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7675460 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7675460 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7675460 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7675460 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:7675460 | pubmed:author | pubmed-author:SunS CSC | lld:pubmed |
| pubmed-article:7675460 | pubmed:author | pubmed-author:MaggirwarS... | lld:pubmed |
| pubmed-article:7675460 | pubmed:author | pubmed-author:HarhajEE | lld:pubmed |
| pubmed-article:7675460 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7675460 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:7675460 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:7675460 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7675460 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7675460 | pubmed:pagination | 993-8 | lld:pubmed |
| pubmed-article:7675460 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7675460 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7675460 | pubmed:articleTitle | Activation of NF-kappa B/Rel by Tax involves degradation of I kappa B alpha and is blocked by a proteasome inhibitor. | lld:pubmed |
| pubmed-article:7675460 | pubmed:affiliation | Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey Medical Center, Hershey 17033, USA. | lld:pubmed |
| pubmed-article:7675460 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7675460 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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