| pubmed-article:7675086 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7675086 | lifeskim:mentions | umls-concept:C0007090 | lld:lifeskim |
| pubmed-article:7675086 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:7675086 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7675086 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:7675086 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7675086 | lifeskim:mentions | umls-concept:C1337030 | lld:lifeskim |
| pubmed-article:7675086 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:7675086 | lifeskim:mentions | umls-concept:C0015249 | lld:lifeskim |
| pubmed-article:7675086 | pubmed:issue | 6545 | lld:pubmed |
| pubmed-article:7675086 | pubmed:dateCreated | 1995-10-13 | lld:pubmed |
| pubmed-article:7675086 | pubmed:abstractText | Xeroderma pigmentosum patients with a defect in the nucleotide-excision repair gene XPA are characterized by, for example, a > 1,000-fold higher risk of developing sunlight-induced skin cancer. Nucleotide-excision repair (NER) is involved in the removal of a wide spectrum of DNA lesions. The XPA protein functions in a pre-incision step, the recognition of DNA damage. To permit the functional analysis of the XPA gene in vivo, we have generated XPA-deficient mice by gene targeting in embryonic stem cells. The XPA-/-mice appear normal, at least until the age of 13 months. XPA-/-mice are highly susceptible to ultraviolet (UV)-B-induced skin and eye tumours and to 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin tumours. We conclude that the XPA-deficient mice strongly mimic the phenotype of humans with xeroderma pigmentosum. | lld:pubmed |
| pubmed-article:7675086 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7675086 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7675086 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7675086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7675086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7675086 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7675086 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7675086 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7675086 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:7675086 | pubmed:author | pubmed-author:de VriesAA | lld:pubmed |
| pubmed-article:7675086 | pubmed:author | pubmed-author:HofhuisF MFM | lld:pubmed |
| pubmed-article:7675086 | pubmed:author | pubmed-author:CapelP JPJ | lld:pubmed |
| pubmed-article:7675086 | pubmed:author | pubmed-author:WesterP WPW | lld:pubmed |
| pubmed-article:7675086 | pubmed:author | pubmed-author:van SteegHH | lld:pubmed |
| pubmed-article:7675086 | pubmed:author | pubmed-author:de GruijlF... | lld:pubmed |
| pubmed-article:7675086 | pubmed:author | pubmed-author:van KreijlC... | lld:pubmed |
| pubmed-article:7675086 | pubmed:author | pubmed-author:AONOKK | lld:pubmed |
| pubmed-article:7675086 | pubmed:author | pubmed-author:van... | lld:pubmed |
| pubmed-article:7675086 | pubmed:author | pubmed-author:DortantP MPM | lld:pubmed |
| pubmed-article:7675086 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7675086 | pubmed:day | 14 | lld:pubmed |
| pubmed-article:7675086 | pubmed:volume | 377 | lld:pubmed |
| pubmed-article:7675086 | pubmed:geneSymbol | XPA | lld:pubmed |
| pubmed-article:7675086 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7675086 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:7675086 | pubmed:pagination | 169-73 | lld:pubmed |
| pubmed-article:7675086 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7675086 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7675086 | pubmed:articleTitle | Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. | lld:pubmed |
| pubmed-article:7675086 | pubmed:affiliation | Department of Immunology, University of Utrecht, The Netherlands. | lld:pubmed |
| pubmed-article:7675086 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7675086 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:22590 | entrezgene:pubmed | pubmed-article:7675086 | lld:entrezgene |
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