Linked Life Data

7674700

Source:http://linkedlifedata.com/resource/pubmed/id/7674700

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pubmed-article:7674700pubmed:dateCreated1995-10-19lld:pubmed
pubmed-article:7674700pubmed:abstractTextThe relative bioavailability of ketoprofen from a liquid formulation as compared to a tablet formulation as reference after single oral dose administration was investigated in 16 healthy male subjects. The subjects received in a randomized, crossover design during one study period of 5 days 2.5 mg of ketoprofen as tablet or liquid formulation administered as single dose with a washout interval of 48 h. The plasma concentrations of S(+)- and R(-)-ketoprofen were determined before and up to 24 h post-administration. S(+)- and R(-)-ketoprofen in the collected plasma samples was determined using an internally standardized validated HPLC method. Regarding the geometric mean concentration-time courses there were no relevant differences between the two ketoprofen enantiomers for both formulations. Remarkable differences in the shape of concentration-time courses between the two formulations were found with higher Cmax (by about 70%) and earlier tmax (by 15 min) values for the ketoprofen solution. The treatments were widely equivalent with regard to AUC. The quotients of geometric means as well as 90% confidence intervals for AUC of R(-)-ketoprofen were 95.72% (92.55-99.00%) and for S(+)-ketoprofen 94.23% (89.91-98.76%). The administration of the ketoprofen solution resulted earlier in higher concentrations (by about 70%) for both enantiomers, whereas the extent of absorption expressed by AUC was nearly the same (about 95%) as compared to the equimolar tablet formulation. The differences between the two formulations for Cmax,norm and tmax were statistically significant.lld:pubmed
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pubmed-article:7674700pubmed:pagination129-34lld:pubmed
pubmed-article:7674700pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:7674700pubmed:year1995lld:pubmed
pubmed-article:7674700pubmed:articleTitlePharmacokinetics and relative bioavailability after single dose administration of 25 mg ketoprofen solution as compared to tablets.lld:pubmed
pubmed-article:7674700pubmed:affiliationInstitut für klinische Pharmakologie Bobenheim, Prof. Dr. Lücker GmbH, Grünstadt, Germany.lld:pubmed
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pubmed-article:7674700pubmed:publicationTypeRandomized Controlled Triallld:pubmed