| pubmed-article:7673243 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7673243 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7673243 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:7673243 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:7673243 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:7673243 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:7673243 | lifeskim:mentions | umls-concept:C0053932 | lld:lifeskim |
| pubmed-article:7673243 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:7673243 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:7673243 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:7673243 | pubmed:issue | 38 | lld:pubmed |
| pubmed-article:7673243 | pubmed:dateCreated | 1995-10-17 | lld:pubmed |
| pubmed-article:7673243 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7673243 | pubmed:abstractText | Bone morphogenetic proteins (BMPs) comprise the largest subfamily of TGF-beta-related ligands and are known to bind to type I and type II receptor serine/threonine kinases. Although several mammalian BMP type I receptors have been identified, the mammalian BMP type II receptors have remained elusive. We have isolated a cDNA encoding a novel transmembrane serine/threonine kinase from human skin fibroblasts which we demonstrate here to be a type II receptor that binds BMP-4. This receptor (BRK-3) is distantly related to other known type II receptors and is distinguished from them by an extremely long carboxyl-terminal sequence following the intracellular kinase domain. The BRK-3 gene is widely expressed in a variety of adult tissues. When expressed alone in COS cells, BRK-3 specifically binds BMP-4, but cross-linking of BMP-4 to BRK-3 is undetectable in the absence of either the BRK-1 or BRK-2 BMP type I receptors. Cotransfection of BRK-2 with BRK-3 greatly enhanced affinity labeling of BMP-4 to the type I receptor, in contrast to the affinity labeling pattern observed with the BRK-1 + BRK-3 heteromeric complex. Furthermore, a subpopulation of super-high affinity binding sites is formed in COS cells upon cotransfection only of BRK-2 + BRK-3, suggesting that the different heteromeric BMP receptor complexes have different signaling potential. | lld:pubmed |
| pubmed-article:7673243 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7673243 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7673243 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7673243 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7673243 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7673243 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7673243 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7673243 | pubmed:author | pubmed-author:SaitoTT | lld:pubmed |
| pubmed-article:7673243 | pubmed:author | pubmed-author:IshikawaTT | lld:pubmed |
| pubmed-article:7673243 | pubmed:author | pubmed-author:HosokawaKK | lld:pubmed |
| pubmed-article:7673243 | pubmed:author | pubmed-author:NojiSS | lld:pubmed |
| pubmed-article:7673243 | pubmed:author | pubmed-author:NohnoTT | lld:pubmed |
| pubmed-article:7673243 | pubmed:author | pubmed-author:RosenbaumJ... | lld:pubmed |
| pubmed-article:7673243 | pubmed:author | pubmed-author:WolsingD HDH | lld:pubmed |
| pubmed-article:7673243 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7673243 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:7673243 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:7673243 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7673243 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7673243 | pubmed:pagination | 22522-6 | lld:pubmed |
| pubmed-article:7673243 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7673243 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7673243 | pubmed:articleTitle | Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors. | lld:pubmed |
| pubmed-article:7673243 | pubmed:affiliation | Department of Pharmacology, Kawasaki Medical School, Japan. | lld:pubmed |
| pubmed-article:7673243 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7673243 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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