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pubmed-article:7667386pubmed:abstractTextBehavioral deficits following inescapable stress (learned helplessness) may serve as an animal model of depression. Previous studies using foot-shock stress to induce learned helplessness and a bar-press test for the stress-induced behavioral deficit have found increased beta-adrenergic receptor density in the hippocampus of learned helpless rats. We replicated these experiments using a tail-shock stress and the shuttle-box test. In our experiments, rats that developed learned helplessness after inescapable stress did not demonstrate any significant differences in beta-adrenergic receptor density or affinity in the frontal cortex, cerebellum, or hippocampus compared to the nonhelpless rats, nor to the tested control rats. These results suggest that beta-adrenergic receptor changes in learned helplessness may depend on the specific stress and test procedures used.lld:pubmed
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pubmed-article:7667386pubmed:articleTitleBeta-adrenergic receptor changes in learned helplessness may depend on stress and test parameters.lld:pubmed
pubmed-article:7667386pubmed:affiliationDepartment of Psychiatry, University of Texas Health Science Center at San Antonio, USA.lld:pubmed
pubmed-article:7667386pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7667386pubmed:publicationTypeResearch Support, U.S. Gov't, Non-P.H.S.lld:pubmed