| pubmed-article:7667103 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7667103 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:7667103 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:7667103 | lifeskim:mentions | umls-concept:C1419989 | lld:lifeskim |
| pubmed-article:7667103 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:7667103 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:7667103 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:7667103 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:7667103 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:7667103 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:7667103 | lifeskim:mentions | umls-concept:C0887917 | lld:lifeskim |
| pubmed-article:7667103 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:7667103 | pubmed:dateCreated | 1995-10-11 | lld:pubmed |
| pubmed-article:7667103 | pubmed:abstractText | Members of the SR family of proteins, can collaborate with U1 snRNP in the recognition of 5' splice sites in pre-messenger RNAs. We have previously shown that purified U1 snRNP and ASF/SF2 form a ternary complex with pre-mRNA, which is dependent on a functional 5' splice site. In this manuscript we dissect the requirements for the formation of this complex. Sequences in the pre-mRNA, domains in ASF/SF2 and components of the U1 snRNP particle are shown to be required for complex formation. We had shown that sequences at the 5' splice site of PIP7. A are necessary and now we show these are sufficient for complex formation. Furthermore, we show that one functional RNA binding domain and the RS domain are both required for ASF/SF2 to participate in complex formation. The RNA binding domains were redundant in this assay, suggesting that either domain can interact with the pre-messenger RNA. Finally, our experiments show no function for the U1-specific A protein in complex formation, whereas a function for U1-specific C protein was strongly suggested. The study of the earliest interactions between pre-mRNA and splicing factors suggests a model for 5' splice site recognition. | lld:pubmed |
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| pubmed-article:7667103 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7667103 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7667103 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7667103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7667103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7667103 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7667103 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7667103 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:7667103 | pubmed:author | pubmed-author:WangJJ | lld:pubmed |
| pubmed-article:7667103 | pubmed:author | pubmed-author:ManleyJ LJL | lld:pubmed |
| pubmed-article:7667103 | pubmed:author | pubmed-author:WillCC | lld:pubmed |
| pubmed-article:7667103 | pubmed:author | pubmed-author:Garcia-Blanco... | lld:pubmed |
| pubmed-article:7667103 | pubmed:author | pubmed-author:LührmannRR | lld:pubmed |
| pubmed-article:7667103 | pubmed:author | pubmed-author:JamisonS FSF | lld:pubmed |
| pubmed-article:7667103 | pubmed:author | pubmed-author:PasmanZZ | lld:pubmed |
| pubmed-article:7667103 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7667103 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:7667103 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:7667103 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7667103 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7667103 | pubmed:pagination | 3260-7 | lld:pubmed |
| pubmed-article:7667103 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:7667103 | pubmed:meshHeading | pubmed-meshheading:7667103-... | lld:pubmed |
| pubmed-article:7667103 | pubmed:meshHeading | pubmed-meshheading:7667103-... | lld:pubmed |
| pubmed-article:7667103 | pubmed:meshHeading | pubmed-meshheading:7667103-... | lld:pubmed |
| pubmed-article:7667103 | pubmed:meshHeading | pubmed-meshheading:7667103-... | lld:pubmed |
