| pubmed-article:7666054 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7666054 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:7666054 | lifeskim:mentions | umls-concept:C2700455 | lld:lifeskim |
| pubmed-article:7666054 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:7666054 | lifeskim:mentions | umls-concept:C0332197 | lld:lifeskim |
| pubmed-article:7666054 | lifeskim:mentions | umls-concept:C0205161 | lld:lifeskim |
| pubmed-article:7666054 | lifeskim:mentions | umls-concept:C1947974 | lld:lifeskim |
| pubmed-article:7666054 | lifeskim:mentions | umls-concept:C1720655 | lld:lifeskim |
| pubmed-article:7666054 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7666054 | pubmed:dateCreated | 1995-10-6 | lld:pubmed |
| pubmed-article:7666054 | pubmed:abstractText | Adult human nerve cells contain tau protein, a phosphorylated microtubule-associated protein, that is hyperphosphorylated in the fetus and in patients with Alzheimer's disease. Hyperphosphorylation, which diminishes the microtubule-binding capacity of tau, destabilizes microtubules and may enhance the formation of paired helical filaments that constitute neurofibrillary tangles in Alzheimer's disease. Here, we use phosphorylation-dependent anti-tau antibodies to detect specific epitopes that characterize hyperphosphorylated tau. Our demonstration of intracellular tangles containing full-length tau that are not immunolabeled by these antibodies suggests that hyperphosphorylation of tau is not obligatory in the formation of neurofibrillary tangles in Alzheimer's disease. | lld:pubmed |
| pubmed-article:7666054 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7666054 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7666054 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7666054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7666054 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7666054 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7666054 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7666054 | pubmed:issn | 0022-3069 | lld:pubmed |
| pubmed-article:7666054 | pubmed:author | pubmed-author:RothMM | lld:pubmed |
| pubmed-article:7666054 | pubmed:author | pubmed-author:BondareffWW | lld:pubmed |
| pubmed-article:7666054 | pubmed:author | pubmed-author:WischikC MCM | lld:pubmed |
| pubmed-article:7666054 | pubmed:author | pubmed-author:HarringtonC... | lld:pubmed |
| pubmed-article:7666054 | pubmed:author | pubmed-author:HauserD LDL | lld:pubmed |
| pubmed-article:7666054 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7666054 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:7666054 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7666054 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7666054 | pubmed:pagination | 657-63 | lld:pubmed |
| pubmed-article:7666054 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7666054 | pubmed:meshHeading | pubmed-meshheading:7666054-... | lld:pubmed |
| pubmed-article:7666054 | pubmed:meshHeading | pubmed-meshheading:7666054-... | lld:pubmed |
| pubmed-article:7666054 | pubmed:meshHeading | pubmed-meshheading:7666054-... | lld:pubmed |
| pubmed-article:7666054 | pubmed:meshHeading | pubmed-meshheading:7666054-... | lld:pubmed |
| pubmed-article:7666054 | pubmed:meshHeading | pubmed-meshheading:7666054-... | lld:pubmed |
| pubmed-article:7666054 | pubmed:meshHeading | pubmed-meshheading:7666054-... | lld:pubmed |
| pubmed-article:7666054 | pubmed:meshHeading | pubmed-meshheading:7666054-... | lld:pubmed |
| pubmed-article:7666054 | pubmed:meshHeading | pubmed-meshheading:7666054-... | lld:pubmed |
| pubmed-article:7666054 | pubmed:meshHeading | pubmed-meshheading:7666054-... | lld:pubmed |
| pubmed-article:7666054 | pubmed:meshHeading | pubmed-meshheading:7666054-... | lld:pubmed |
| pubmed-article:7666054 | pubmed:meshHeading | pubmed-meshheading:7666054-... | lld:pubmed |
| pubmed-article:7666054 | pubmed:meshHeading | pubmed-meshheading:7666054-... | lld:pubmed |
| pubmed-article:7666054 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7666054 | pubmed:articleTitle | Absence of abnormal hyperphosphorylation of tau in intracellular tangles in Alzheimer's disease. | lld:pubmed |
| pubmed-article:7666054 | pubmed:affiliation | Department of Psychiatry and the Behavioral Sciences, University of Southern California Medical School, Los Angeles 90033, USA. | lld:pubmed |
| pubmed-article:7666054 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7666054 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7666054 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7666054 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7666054 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7666054 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7666054 | lld:pubmed |
