| pubmed-article:7658466 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:7658466 | lifeskim:mentions | umls-concept:C0017428 | lld:lifeskim |
| pubmed-article:7658466 | lifeskim:mentions | umls-concept:C0006556 | lld:lifeskim |
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| pubmed-article:7658466 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:7658466 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:7658466 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:7658466 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:7658466 | lifeskim:mentions | umls-concept:C0205197 | lld:lifeskim |
| pubmed-article:7658466 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:7658466 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:7658466 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:7658466 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:7658466 | lifeskim:mentions | umls-concept:C2348205 | lld:lifeskim |
| pubmed-article:7658466 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7658466 | pubmed:dateCreated | 1995-10-2 | lld:pubmed |
| pubmed-article:7658466 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7658466 | pubmed:abstractText | The gene tpa-1 on chromosome IV of the nematode Caenorhabditis elegans plays a major and definitive role in the adversary action of tumour-promoting phorbol esters, which induce growth arrest and locomotory distress in the animal. The gene was deduced to code for a protein kinase C (PKC) homologue by molecular cloning. We have now sequenced the complete genomic and complementary DNAs for tpa-1 and have analysed their structural features in detail: (1) tpa-1 spans over 20 kb consisting of eleven exons and ten introns; (2) two different-sized mRNAs are generated from the tpa-1 locus; (3) both mRNAs are trans-spliced to the trans-spliced leader SL1; (4) both mRNAs encode PKC isoforms, which are most similar to Ca(2+)-independent novel PKC0; (5) the two PKC isoforms differ from each other in that the smaller lacks the amino-terminal region of the larger corresponding to the first four exons and a portion of the fifth exon; and (6) three introns are located at; identical positions in the polypeptide sequences aligned between the C. elegans tpa-1 product and a PKC of the fruit fly Drosophila melanogaster. | lld:pubmed |
| pubmed-article:7658466 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7658466 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7658466 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7658466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7658466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7658466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7658466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7658466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7658466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7658466 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7658466 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7658466 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7658466 | pubmed:issn | 0022-2836 | lld:pubmed |
| pubmed-article:7658466 | pubmed:author | pubmed-author:SanoTT | lld:pubmed |
| pubmed-article:7658466 | pubmed:author | pubmed-author:NishiwakiKK | lld:pubmed |
| pubmed-article:7658466 | pubmed:author | pubmed-author:TabuseYY | lld:pubmed |
| pubmed-article:7658466 | pubmed:author | pubmed-author:MiwaJJ | lld:pubmed |
| pubmed-article:7658466 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7658466 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:7658466 | pubmed:volume | 251 | lld:pubmed |
| pubmed-article:7658466 | pubmed:geneSymbol | tpa-1 | lld:pubmed |
| pubmed-article:7658466 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7658466 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7658466 | pubmed:pagination | 477-85 | lld:pubmed |
| pubmed-article:7658466 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7658466 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7658466 | pubmed:articleTitle | The tpa-1 gene of Caenorhabditis elegans encodes two proteins similar to Ca(2+)-independent protein kinase Cs: evidence by complete genomic and complementary DNA sequences of the tpa-1 gene. | lld:pubmed |
| pubmed-article:7658466 | pubmed:affiliation | Fundamental Research Laboratories, NEC Corporation, Tsukuba, Japan. | lld:pubmed |
| pubmed-article:7658466 | pubmed:publicationType | Journal Article | lld:pubmed |
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