| pubmed-article:7657705 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7657705 | lifeskim:mentions | umls-concept:C0062503 | lld:lifeskim |
| pubmed-article:7657705 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:7657705 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:7657705 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:7657705 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7657705 | lifeskim:mentions | umls-concept:C1415196 | lld:lifeskim |
| pubmed-article:7657705 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:7657705 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:7657705 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:7657705 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:7657705 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7657705 | pubmed:dateCreated | 1995-10-2 | lld:pubmed |
| pubmed-article:7657705 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7657705 | pubmed:abstractText | Glypicans are a family of glycosylphosphatidylinositol (GPI)-anchored cell surface heparan sulfate proteoglycans (HSPGs). The glypican family, which currently includes glypican, the developmentally regulated rat intestinal transcript OCI-5, and cerebroglycan, is characterized by a similar core protein size and almost complete conservation of cysteine residues. By RT-PCR using degenerate oligonucleotide primers based on the sequence homologies, we isolated mouse cDNA encoding a novel member of the glypican family as well as mouse homologues of glypican and OCI-5. The novel molecule, named K-glypican, has a predicted molecular mass of 57.5 kD and potential attachment sites for heparan sulfate chains and a GPI anchor in its COOH-terminal region, like other members of the glypican family. Transfection of an epitope-tagged full-length K-glypican cDNA into MDCK cells demonstrated that K-glypican is indeed expressed as a GPI-anchored HSPG. Northern blot analyses with K-glypican, glypican, and OCI-5 probes demonstrated that kidney and developing brain, and that these three molecules show remarkable patterns of cell type- and developmental stage-specific expression. In situ hybridization revealed that the major sites of K-glypican expression in developing embryo are tubular epithelial cells in the kidney and proliferating neuroepithelial cells in the brain. These results indicate that K-glypican is a novel GPI-anchored HSPG involved in embryonic development. | lld:pubmed |
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| pubmed-article:7657705 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7657705 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7657705 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7657705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7657705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7657705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7657705 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7657705 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7657705 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7657705 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:7657705 | pubmed:author | pubmed-author:WatanabeKK | lld:pubmed |
| pubmed-article:7657705 | pubmed:author | pubmed-author:YamadaHH | lld:pubmed |
| pubmed-article:7657705 | pubmed:author | pubmed-author:YamaguchiYY | lld:pubmed |
| pubmed-article:7657705 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7657705 | pubmed:volume | 130 | lld:pubmed |
| pubmed-article:7657705 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7657705 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7657705 | pubmed:pagination | 1207-18 | lld:pubmed |
| pubmed-article:7657705 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7657705 | pubmed:meshHeading | pubmed-meshheading:7657705-... | lld:pubmed |
| pubmed-article:7657705 | pubmed:meshHeading | pubmed-meshheading:7657705-... | lld:pubmed |
| pubmed-article:7657705 | pubmed:meshHeading | pubmed-meshheading:7657705-... | lld:pubmed |
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| pubmed-article:7657705 | pubmed:meshHeading | pubmed-meshheading:7657705-... | lld:pubmed |
