pubmed-article:7657508 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:7657508 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:7657508 | lifeskim:mentions | umls-concept:C0025202 | lld:lifeskim |
pubmed-article:7657508 | lifeskim:mentions | umls-concept:C0449258 | lld:lifeskim |
pubmed-article:7657508 | lifeskim:mentions | umls-concept:C0300500 | lld:lifeskim |
pubmed-article:7657508 | pubmed:issue | 1-6 | lld:pubmed |
pubmed-article:7657508 | pubmed:dateCreated | 1995-10-3 | lld:pubmed |
pubmed-article:7657508 | pubmed:abstractText | Melanoma often develops from clinically and histologically well-defined precursor lesions. During progression of normal melanocytes to benign nevi, dramatic changes in the expression of adhesion receptors are observed, most notably loss of E-cadherin which mediates adhesion of melanocytes to keratinocytes, and gain of Mel-CAM which predominantly mediates heterotypic adhesion between cells. Major changes in adhesion receptors also occur when cells progress from dysplastic nevi or biologically early radial-growth-phase primary melanomas to biologically late (tumorigenic) vertical-growth-phase primary melanomas. The integrin subunit beta 3 is up-regulated, whereas other integrins such as alpha 6 beta 1 and alpha V beta 1 are down-regulated. This review highlights the major changes in adhesion receptor expression on melanocytes at various stages of tumor progression. | lld:pubmed |
pubmed-article:7657508 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7657508 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7657508 | pubmed:language | eng | lld:pubmed |
pubmed-article:7657508 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7657508 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:7657508 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7657508 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:7657508 | pubmed:issn | 0251-1789 | lld:pubmed |
pubmed-article:7657508 | pubmed:author | pubmed-author:HerlynMM | lld:pubmed |
pubmed-article:7657508 | pubmed:author | pubmed-author:NesbitMM | lld:pubmed |
pubmed-article:7657508 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:7657508 | pubmed:volume | 14 | lld:pubmed |
pubmed-article:7657508 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:7657508 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:7657508 | pubmed:pagination | 131-46 | lld:pubmed |
pubmed-article:7657508 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
pubmed-article:7657508 | pubmed:meshHeading | pubmed-meshheading:7657508-... | lld:pubmed |
pubmed-article:7657508 | pubmed:meshHeading | pubmed-meshheading:7657508-... | lld:pubmed |
pubmed-article:7657508 | pubmed:meshHeading | pubmed-meshheading:7657508-... | lld:pubmed |
pubmed-article:7657508 | pubmed:meshHeading | pubmed-meshheading:7657508-... | lld:pubmed |
pubmed-article:7657508 | pubmed:meshHeading | pubmed-meshheading:7657508-... | lld:pubmed |
pubmed-article:7657508 | pubmed:meshHeading | pubmed-meshheading:7657508-... | lld:pubmed |
pubmed-article:7657508 | pubmed:meshHeading | pubmed-meshheading:7657508-... | lld:pubmed |
pubmed-article:7657508 | pubmed:articleTitle | Adhesion receptors in human melanoma progression. | lld:pubmed |
pubmed-article:7657508 | pubmed:affiliation | Wistar Institute, Philadelphia, Pa 19104-4268, USA. | lld:pubmed |
pubmed-article:7657508 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:7657508 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:7657508 | pubmed:publicationType | Review | lld:pubmed |
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