| pubmed-article:7657047 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7657047 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7657047 | lifeskim:mentions | umls-concept:C0023516 | lld:lifeskim |
| pubmed-article:7657047 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
| pubmed-article:7657047 | lifeskim:mentions | umls-concept:C0439793 | lld:lifeskim |
| pubmed-article:7657047 | lifeskim:mentions | umls-concept:C0679408 | lld:lifeskim |
| pubmed-article:7657047 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:7657047 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7657047 | pubmed:dateCreated | 1995-9-29 | lld:pubmed |
| pubmed-article:7657047 | pubmed:abstractText | The objective of this study was to determine the role of cyclosporin A (CsA) on cold-restraint-induced gastric lesions. Animals were subjected to 3 h immobilization at 4 degrees C in plastic restraining devices following a starvation period of 48 h. Gastric samples were obtained for the measurement of myeloperoxidase (MPO) activity, an index of number of peroxidase positive cells and thiobarbituric acid-reactive substances (TBARS; lipid peroxidation). Animals were pretreated with CsA which is a potent immunosuppressant and inhibits ischemia/reperfusion-induced polymorphonuclear leukocyte (PMN) infiltration. Cold-restraint administration significantly elevated the tissue MPO activity and TBARS formation. CsA pretreatment significantly reduced the severity of cold-restraint-induced gastric lesions while attenuating the elevated MPO measurements observed during cold-restraint administration. Animals rendered neutropenic with antineutrophil serum (ANS) exhibited significantly less gastric mucosal injury normally observed after cold-restraint stress. Neither CsA nor ANS treatment effected the elevated TBAR levels, indicating that PMNs are not involved in the lipid peroxidation process observed after cold-restraint stress. In conclusion, the results of this study indicate that CsA is capable of inhibiting cold-restraint-induced gastric mucosal injury and can attenuate the cold-restraint-induced increases in gastric MPO measurements. Our results also indicate that PMNs may be the important mediators of cold-restraint-induced gastric lesions. | lld:pubmed |
| pubmed-article:7657047 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7657047 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7657047 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7657047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7657047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7657047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7657047 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7657047 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7657047 | pubmed:issn | 0012-2823 | lld:pubmed |
| pubmed-article:7657047 | pubmed:author | pubmed-author:Co?kunTT | lld:pubmed |
| pubmed-article:7657047 | pubmed:author | pubmed-author:KurtelHH | lld:pubmed |
| pubmed-article:7657047 | pubmed:author | pubmed-author:AlicanII | lld:pubmed |
| pubmed-article:7657047 | pubmed:author | pubmed-author:SauSS | lld:pubmed |
| pubmed-article:7657047 | pubmed:author | pubmed-author:Ye?enB CBC | lld:pubmed |
| pubmed-article:7657047 | pubmed:author | pubmed-author:CetinelSS | lld:pubmed |
| pubmed-article:7657047 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7657047 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:7657047 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7657047 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7657047 | pubmed:pagination | 214-9 | lld:pubmed |
| pubmed-article:7657047 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:7657047 | pubmed:meshHeading | pubmed-meshheading:7657047-... | lld:pubmed |
| pubmed-article:7657047 | pubmed:meshHeading | pubmed-meshheading:7657047-... | lld:pubmed |
| pubmed-article:7657047 | pubmed:meshHeading | pubmed-meshheading:7657047-... | lld:pubmed |
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| pubmed-article:7657047 | pubmed:meshHeading | pubmed-meshheading:7657047-... | lld:pubmed |
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| pubmed-article:7657047 | pubmed:meshHeading | pubmed-meshheading:7657047-... | lld:pubmed |
| pubmed-article:7657047 | pubmed:meshHeading | pubmed-meshheading:7657047-... | lld:pubmed |
| pubmed-article:7657047 | pubmed:meshHeading | pubmed-meshheading:7657047-... | lld:pubmed |
| pubmed-article:7657047 | pubmed:meshHeading | pubmed-meshheading:7657047-... | lld:pubmed |
| pubmed-article:7657047 | pubmed:meshHeading | pubmed-meshheading:7657047-... | lld:pubmed |
| pubmed-article:7657047 | pubmed:meshHeading | pubmed-meshheading:7657047-... | lld:pubmed |
| pubmed-article:7657047 | pubmed:meshHeading | pubmed-meshheading:7657047-... | lld:pubmed |
| pubmed-article:7657047 | pubmed:meshHeading | pubmed-meshheading:7657047-... | lld:pubmed |
| pubmed-article:7657047 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7657047 | pubmed:articleTitle | Cyclosporin A reduces the severity of cold-restraint-induced gastric lesions: role of leukocytes. | lld:pubmed |
| pubmed-article:7657047 | pubmed:affiliation | Department of Physiology, Marmara University School of Medicine, Istanbul, Turkey. | lld:pubmed |
| pubmed-article:7657047 | pubmed:publicationType | Journal Article | lld:pubmed |
