| pubmed-article:7654318 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7654318 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:7654318 | lifeskim:mentions | umls-concept:C0029016 | lld:lifeskim |
| pubmed-article:7654318 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:7654318 | lifeskim:mentions | umls-concept:C1158884 | lld:lifeskim |
| pubmed-article:7654318 | pubmed:issue | 11-12 | lld:pubmed |
| pubmed-article:7654318 | pubmed:dateCreated | 1995-10-5 | lld:pubmed |
| pubmed-article:7654318 | pubmed:abstractText | The antiapoptosis potential of bcl-2 has now been well established. But the biochemical mechanism of bcl-2 action is still poorly understood. Using the phosphatase inhibitor okadaic acid (OA) or chemotherapeutic agents such as Taxol and 5'-fluorouracil, we found that bcl-2 can be phosphorylated. Since OA or Taxol treatment leads to apoptosis, it seems that phosphorylation of bcl-2 leads to its inactivation. Exposure of several lymphoid cell lines expressing differential amounts of bcl-2 protein to OA resulted in apoptosis of the cells and hyperphosphorylation of bcl-2. Interestingly, the lymphoblastoid cell lines that did not phosphorylate bcl-2 following OA exposure did not undergo apoptosis. Moreover, pro-B cells isolated from patients with acute lymphoblastic leukemias exhibited endogenous phosphorylated forms of bcl-2 and a large number of apoptotic cells, even without OA treatment. Treatment with the phosphatase inhibitor or with chemotherapeutic agents (Taxol, 5'-fluorouracil) led to severe apoptosis of these cells, along with hyperphosphorylation of bcl-2. Phosphoamino acid analysis reveals that bcl-2 is phosphorylated at a serine residue. In summary, our investigation indicates that the phosphorylation pathway involving bcl-2 can be the determinant of cell death in lymphocytes. | lld:pubmed |
| pubmed-article:7654318 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7654318 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7654318 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7654318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7654318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7654318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7654318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7654318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7654318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7654318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7654318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7654318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7654318 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7654318 | pubmed:issn | 0829-8211 | lld:pubmed |
| pubmed-article:7654318 | pubmed:author | pubmed-author:CroceC MCM | lld:pubmed |
| pubmed-article:7654318 | pubmed:author | pubmed-author:HaldarSS | lld:pubmed |
| pubmed-article:7654318 | pubmed:author | pubmed-author:JenaNN | lld:pubmed |
| pubmed-article:7654318 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7654318 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:7654318 | pubmed:geneSymbol | bcl-2 | lld:pubmed |
| pubmed-article:7654318 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7654318 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7654318 | pubmed:pagination | 455-62 | lld:pubmed |
| pubmed-article:7654318 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7654318 | pubmed:meshHeading | pubmed-meshheading:7654318-... | lld:pubmed |
| pubmed-article:7654318 | pubmed:articleTitle | Antiapoptosis potential of bcl-2 oncogene by dephosphorylation. | lld:pubmed |
| pubmed-article:7654318 | pubmed:affiliation | Jefferson Cancer Institute, Jefferson Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. | lld:pubmed |
| pubmed-article:7654318 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7654318 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7654318 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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