| pubmed-article:7650378 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7650378 | lifeskim:mentions | umls-concept:C0029246 | lld:lifeskim |
| pubmed-article:7650378 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7650378 | lifeskim:mentions | umls-concept:C1416961 | lld:lifeskim |
| pubmed-article:7650378 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:7650378 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:7650378 | lifeskim:mentions | umls-concept:C1519595 | lld:lifeskim |
| pubmed-article:7650378 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7650378 | pubmed:dateCreated | 1995-9-22 | lld:pubmed |
| pubmed-article:7650378 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7650378 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7650378 | pubmed:abstractText | The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is expressed selectively at venular sites of lymphocyte extravasation into mucosal lymphoid tissues and lamina propria, where it directs local lymphocyte trafficking. MAdCAM-1 is a multifunctional type l transmembrane adhesion molecule comprising two distal lg domains involved in alpha 4 beta 7 integrin binding, a mucin-like region able to display L-selectin-binding carbohydrates, and a membrane-proximal lg domain homologous to lgA. We show in this work that the MAdCAM-1 gene is located on chromosome 10 and contains five exons. The signal peptide and each one of the three lg domains are encoded by a distinct exon, whereas the transmembrane, cytoplasmic tail, and 3'-untranslated region of MAdCAM-1 are combined on a single exon. The mucin-like region and the third lg domain are encoded together on exon 4. An alternatively spliced MAdCAM-1 mRNA is identified that lacks the mucin/lgA-homologous exon 4-encoded sequences. This short variant of MAdCAM-1 may be specialized to support alpha 4 beta 7-dependent adhesion strengthening, independent of carbohydrate-presenting function. Sequences 5' of the transcription start site include tandem nuclear factor-kappa B sites; AP-1, AP-2, and signal peptide-1 binding sites; and an estrogen response element. Our findings reinforce the correspondence between the multidomain structure and versatile functions of this vascular addressin, and suggest an additional level of regulation of carbohydrate-presenting capability, and thus of its importance in lectin-mediated vs alpha 4 beta 7-dependent adhesive events in lymphocyte trafficking. | lld:pubmed |
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| pubmed-article:7650378 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7650378 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7650378 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7650378 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7650378 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7650378 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7650378 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7650378 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7650378 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7650378 | pubmed:author | pubmed-author:ButcherE CEC | lld:pubmed |
| pubmed-article:7650378 | pubmed:author | pubmed-author:TakeuchiMM | lld:pubmed |
| pubmed-article:7650378 | pubmed:author | pubmed-author:FranckeUU | lld:pubmed |
| pubmed-article:7650378 | pubmed:author | pubmed-author:LULL | lld:pubmed |
| pubmed-article:7650378 | pubmed:author | pubmed-author:deL GLG | lld:pubmed |
| pubmed-article:7650378 | pubmed:author | pubmed-author:BrissieE OEO | lld:pubmed |
| pubmed-article:7650378 | pubmed:author | pubmed-author:SampaioS OSO | lld:pubmed |
| pubmed-article:7650378 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7650378 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7650378 | pubmed:volume | 155 | lld:pubmed |
| pubmed-article:7650378 | pubmed:geneSymbol | MAdCAM-1 | lld:pubmed |
| pubmed-article:7650378 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7650378 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7650378 | pubmed:pagination | 2477-86 | lld:pubmed |
| pubmed-article:7650378 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7650378 | pubmed:meshHeading | pubmed-meshheading:7650378-... | lld:pubmed |
| pubmed-article:7650378 | pubmed:meshHeading | pubmed-meshheading:7650378-... | lld:pubmed |
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| pubmed-article:7650378 | pubmed:meshHeading | pubmed-meshheading:7650378-... | lld:pubmed |
| pubmed-article:7650378 | pubmed:meshHeading | pubmed-meshheading:7650378-... | lld:pubmed |
| pubmed-article:7650378 | pubmed:meshHeading | pubmed-meshheading:7650378-... | lld:pubmed |
| pubmed-article:7650378 | pubmed:meshHeading | pubmed-meshheading:7650378-... | lld:pubmed |
| pubmed-article:7650378 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7650378 | pubmed:articleTitle | Organization, regulatory sequences, and alternatively spliced transcripts of the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) gene. | lld:pubmed |
| pubmed-article:7650378 | pubmed:affiliation | Department of Pathology, Stanford University School of Medicine, CA 94305, USA. | lld:pubmed |
| pubmed-article:7650378 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7650378 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7650378 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7650378 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:17123 | entrezgene:pubmed | pubmed-article:7650378 | lld:entrezgene |
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