| pubmed-article:7649354 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7649354 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7649354 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7649354 | lifeskim:mentions | umls-concept:C0036884 | lld:lifeskim |
| pubmed-article:7649354 | lifeskim:mentions | umls-concept:C1819435 | lld:lifeskim |
| pubmed-article:7649354 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:7649354 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7649354 | pubmed:dateCreated | 1995-9-28 | lld:pubmed |
| pubmed-article:7649354 | pubmed:abstractText | The mechanisms by which the sex hormones achieve their bone-sparing effects remains unresolved. Interleukin-1 beta (IL-1 beta) is an autocrine/paracrine regulator of bone that may be produced in an estrogen-sensitive manner. The regulation of IL-1 beta production by the gonadal steroids was tested in the human osteoblastic HOBIT cell model. Dose-dependent 4-8-fold increases (P < 0.05) in IL-1 beta mRNA levels followed a 6-48 h treatment with 17 beta-estradiol or testosterone. Receptor mediation of these responses was indicated by experiments using 17 alpha-estradiol or flutamide. Tumor necrosis factor-alpha (TNF) dependent increase IL-1 beta mRNA levels were additive to the effects of the steroids. Testosterone and TNF increased IL-1 beta protein release (P < 0.05) while 17 beta-estradiol had little effect on release. The bone-sparing effects of the gonadal steroids may be accomplished, in part, through their mediation of local IL-1 beta production. | lld:pubmed |
| pubmed-article:7649354 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7649354 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7649354 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7649354 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7649354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7649354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7649354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7649354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7649354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7649354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7649354 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7649354 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7649354 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7649354 | pubmed:issn | 0303-7207 | lld:pubmed |
| pubmed-article:7649354 | pubmed:author | pubmed-author:KeetingP EPE | lld:pubmed |
| pubmed-article:7649354 | pubmed:author | pubmed-author:CisselD SDS | lld:pubmed |
| pubmed-article:7649354 | pubmed:author | pubmed-author:PivirottoL... | lld:pubmed |
| pubmed-article:7649354 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7649354 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:7649354 | pubmed:volume | 111 | lld:pubmed |
| pubmed-article:7649354 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7649354 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7649354 | pubmed:pagination | 67-74 | lld:pubmed |
| pubmed-article:7649354 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7649354 | pubmed:meshHeading | pubmed-meshheading:7649354-... | lld:pubmed |
| pubmed-article:7649354 | pubmed:meshHeading | pubmed-meshheading:7649354-... | lld:pubmed |
| pubmed-article:7649354 | pubmed:meshHeading | pubmed-meshheading:7649354-... | lld:pubmed |
| pubmed-article:7649354 | pubmed:meshHeading | pubmed-meshheading:7649354-... | lld:pubmed |
| pubmed-article:7649354 | pubmed:meshHeading | pubmed-meshheading:7649354-... | lld:pubmed |
| pubmed-article:7649354 | pubmed:meshHeading | pubmed-meshheading:7649354-... | lld:pubmed |
| pubmed-article:7649354 | pubmed:meshHeading | pubmed-meshheading:7649354-... | lld:pubmed |
| pubmed-article:7649354 | pubmed:meshHeading | pubmed-meshheading:7649354-... | lld:pubmed |
| pubmed-article:7649354 | pubmed:meshHeading | pubmed-meshheading:7649354-... | lld:pubmed |
| pubmed-article:7649354 | pubmed:meshHeading | pubmed-meshheading:7649354-... | lld:pubmed |
| pubmed-article:7649354 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7649354 | pubmed:articleTitle | Sex hormones mediate interleukin-1 beta production by human osteoblastic HOBIT cells. | lld:pubmed |
| pubmed-article:7649354 | pubmed:affiliation | Department of Biology, West Virginia University, Morgantown 26505-6057, USA. | lld:pubmed |
| pubmed-article:7649354 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7649354 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7649354 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7649354 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7649354 | lld:pubmed |
