| pubmed-article:7647972 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7647972 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7647972 | lifeskim:mentions | umls-concept:C1267092 | lld:lifeskim |
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| pubmed-article:7647972 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:7647972 | lifeskim:mentions | umls-concept:C0299247 | lld:lifeskim |
| pubmed-article:7647972 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:7647972 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:7647972 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:7647972 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:7647972 | lifeskim:mentions | umls-concept:C0682770 | lld:lifeskim |
| pubmed-article:7647972 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:7647972 | lifeskim:mentions | umls-concept:C1282913 | lld:lifeskim |
| pubmed-article:7647972 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
| pubmed-article:7647972 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7647972 | pubmed:dateCreated | 1995-9-26 | lld:pubmed |
| pubmed-article:7647972 | pubmed:abstractText | 1. In isolated circular smooth muscle strips of human colon 5-hydroxytryptamine (5-HT) produced a concentration-related inhibition of spontaneous motility. 2. The azabicycloalkyl benzimidazolones, BIMU 8 and BIMU 1, which have 5-HT4 receptor stimulant properties, inhibited motility with EC50 values of 0.76 microM and 3.19 microM respectively and their Emax values were not significantly different from 5-HT (EC50, 0.13 microM). 3. The 5-HT4 receptor antagonist, DAU 6285 (1-10 microM), displaced the 5-HT concentration-response curve to the right in a parallel concentration-dependent manner without depressing the maximum. The Schild plot was linear and the slope did not differ significantly from unity giving a pA2 value of 6.32. 4. The high affinity selective 5-HT4 receptor antagonist, GR 113808, at a concentration of 3 nM displaced the 5-HT concentration-response curve in a parallel manner giving an apparent pKB estimate of 8.9 +/- 0.24. However, higher concentrations of 10-100 nM GR 113808 did not result in a further significant displacement of the 5-HT concentration-response curve and there was no suppression of Emax. 5. GR 113808 (10 nM) also caused a parallel displacement of the concentration-response curve to the 5-HT4 receptor agonist, 5-methoxytryptamine (5-MeOT) giving apparent pKB values ranging from 8.3-9.3. 6. GR 113808 (3-100 nM) failed to displace 5-HT or 5-MeOT concentration-response curves in tissue strips from 3 patients out of a total of 10 patients studied in whom the response to 5-HT and 5-MeOT was normal. 7. The 5-HT4 receptor antagonist, SDZ 205-557 (0.3-10 microM), had no significant effect on 5-HT-induced inhibition of spontaneous motility.8. The present results are discussed in the light of variability of response to GR 113808 and SDZ205-557 in other tissues.9. Overall, our data indicate that human colon circular smooth muscle can be regarded as a site in which 5-HT4-like receptors are present but it is as yet unclear whether these results are also an indication of receptor variation. | lld:pubmed |
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| pubmed-article:7647972 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7647972 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7647972 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7647972 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7647972 | pubmed:month | May | lld:pubmed |
| pubmed-article:7647972 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:7647972 | pubmed:author | pubmed-author:HillierKK | lld:pubmed |
| pubmed-article:7647972 | pubmed:author | pubmed-author:BunceK TKT | lld:pubmed |
| pubmed-article:7647972 | pubmed:author | pubmed-author:BaoX QXQ | lld:pubmed |
| pubmed-article:7647972 | pubmed:author | pubmed-author:GrossmanCC | lld:pubmed |
| pubmed-article:7647972 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7647972 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:7647972 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7647972 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7647972 | pubmed:pagination | 172-6 | lld:pubmed |
| pubmed-article:7647972 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:7647972 | pubmed:meshHeading | pubmed-meshheading:7647972-... | lld:pubmed |
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| pubmed-article:7647972 | pubmed:meshHeading | pubmed-meshheading:7647972-... | lld:pubmed |
| pubmed-article:7647972 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7647972 | pubmed:articleTitle | Differences in response to 5-HT4 receptor agonists and antagonists of the 5-HT4-like receptor in human colon circular smooth muscle. | lld:pubmed |
| pubmed-article:7647972 | pubmed:affiliation | Clinical Pharmacology Group, Faculty of Medicine, University of Southampton, UK. | lld:pubmed |
| pubmed-article:7647972 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7647972 | pubmed:publicationType | In Vitro | lld:pubmed |
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