| pubmed-article:7642213 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C0241526 | lld:lifeskim |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C0241764 | lld:lifeskim |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C1413221 | lld:lifeskim |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C1705822 | lld:lifeskim |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:7642213 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:7642213 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7642213 | pubmed:dateCreated | 1995-9-21 | lld:pubmed |
| pubmed-article:7642213 | pubmed:abstractText | A novel monoclonal antibody (mAb) was established in an attempt to look for a cell-surface molecule that delivered a signal regulating apoptotic cell death of B cells. Because spleen cells in resting culture die from apoptosis, mAb were looked for that were able to prolong spleen cell survival in vitro. This screening selected mAb CS/2. CS/2 not only prolonged spleen cell survival in vitro, but also protected spleen cells from apoptotic cell death brought about by irradiation or dexamethasone. Moreover, stimulation of spleen cells with CS/2 mAb induced changes of cells to blastoid morphology, and a significant uptake of [3H]thymidine ([3H]TdR). The antigen recognized by CS/2 mAb (CS/2 Ag) was expressed on preB cells, B cells, and Mac-1+ cells. The cells surviving in vitro culture or irradiation in response to ligation with CS/2 mAb were mostly B cells expressing the CS/2 Ag. In addition, B cells from X-linked immunodeficient (XID) mice did not respond to CS/2 mAb. These results indicate that CS/2 mAb is agonistic to B cells, and that XID mice are deficient in this CS/2 mAb-mediated activation pathway. Determination of the amino-terminal 24 amino acid residues revealed that the CS/2 Ag appears to be identical to the CS/2 mAb is directed against a murine CD38 homologue, and suggest a possible role of the murine CD38 homologue in controlling apoptotic cell death of B cells. | lld:pubmed |
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| pubmed-article:7642213 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7642213 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7642213 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7642213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7642213 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7642213 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7642213 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:7642213 | pubmed:author | pubmed-author:KikuchiYY | lld:pubmed |
| pubmed-article:7642213 | pubmed:author | pubmed-author:NodaSS | lld:pubmed |
| pubmed-article:7642213 | pubmed:author | pubmed-author:TakatsuKK | lld:pubmed |
| pubmed-article:7642213 | pubmed:author | pubmed-author:YamashitaYY | lld:pubmed |
| pubmed-article:7642213 | pubmed:author | pubmed-author:KosugeMM | lld:pubmed |
| pubmed-article:7642213 | pubmed:author | pubmed-author:KimotoMM | lld:pubmed |
| pubmed-article:7642213 | pubmed:author | pubmed-author:MiyakeKK | lld:pubmed |
| pubmed-article:7642213 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7642213 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:7642213 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7642213 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7642213 | pubmed:pagination | 248-55 | lld:pubmed |
| pubmed-article:7642213 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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