| pubmed-article:7641467 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7641467 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:7641467 | lifeskim:mentions | umls-concept:C0018951 | lld:lifeskim |
| pubmed-article:7641467 | lifeskim:mentions | umls-concept:C0927195 | lld:lifeskim |
| pubmed-article:7641467 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:7641467 | pubmed:issue | 313 | lld:pubmed |
| pubmed-article:7641467 | pubmed:dateCreated | 1995-9-21 | lld:pubmed |
| pubmed-article:7641467 | pubmed:abstractText | Bone marrow from 5-fluorouracil-treated mice support osteogenesis when cultured in the presence of beta-glycerophosphate and vitamin C. These cultures are unable to support the growth of granulocyte/macrophage colony-forming units for longer than 2 weeks. In contrast, granulocyte/macrophage colony-forming units were detected for more than 6 weeks in interleukin-10 (IL-10)-treated cultures. In addition, IL-10-treated cultures contain long-term culture initiating cells, suggesting the presence of pluripotent hematopoietic cells. Apparently, IL-10 does not directly stimulate the proliferation of granulocyte/macrophage colony-forming units. Interleukin-10 is unable to stimulate [3H]-thymidine incorporation or to increase the number of granulocyte/macrophage colony-forming units in cell suspensions harvested from untreated or interleukin-10-treated bone marrow cultures. Interleukin-10 acts via an indirect pathway. Because exogenous transforming growth factor-beta (TGF-beta) reverses IL-10's stimulatory activity on myeloid progenitors, IL-10 most likely works by blocking TGF-beta synthesis, which acts as an endogenous suppressor of hematopoiesis in osteogenic marrow cultures. This is shown further by the increased numbers of granulocyte/macrophage colony-forming units in cultures treated with neutralizing anti TGF-beta antibodies (1D11.16). Interleukin-10 and 1D11.16 change the cultured bone marrow stroma from an osteogenic into a hematopoietic morphology. It may be that by blocking endogenous TGF-beta production, IL-10 drives marrow mesenchymal cells away from osteogenic differentiation toward hematopoietic support. | lld:pubmed |
| pubmed-article:7641467 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7641467 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7641467 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7641467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7641467 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7641467 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7641467 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7641467 | pubmed:issn | 0009-921X | lld:pubmed |
| pubmed-article:7641467 | pubmed:author | pubmed-author:FallaNN | lld:pubmed |
| pubmed-article:7641467 | pubmed:author | pubmed-author:Van... | lld:pubmed |
| pubmed-article:7641467 | pubmed:author | pubmed-author:Van Den... | lld:pubmed |
| pubmed-article:7641467 | pubmed:author | pubmed-author:de Waal... | lld:pubmed |
| pubmed-article:7641467 | pubmed:author | pubmed-author:DaschJJ | lld:pubmed |
| pubmed-article:7641467 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7641467 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7641467 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7641467 | pubmed:pagination | 103-14 | lld:pubmed |
| pubmed-article:7641467 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7641467 | pubmed:meshHeading | pubmed-meshheading:7641467-... | lld:pubmed |
| pubmed-article:7641467 | pubmed:meshHeading | pubmed-meshheading:7641467-... | lld:pubmed |
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| pubmed-article:7641467 | pubmed:meshHeading | pubmed-meshheading:7641467-... | lld:pubmed |
| pubmed-article:7641467 | pubmed:meshHeading | pubmed-meshheading:7641467-... | lld:pubmed |
| pubmed-article:7641467 | pubmed:meshHeading | pubmed-meshheading:7641467-... | lld:pubmed |
| pubmed-article:7641467 | pubmed:meshHeading | pubmed-meshheading:7641467-... | lld:pubmed |
| pubmed-article:7641467 | pubmed:meshHeading | pubmed-meshheading:7641467-... | lld:pubmed |
| pubmed-article:7641467 | pubmed:meshHeading | pubmed-meshheading:7641467-... | lld:pubmed |
| pubmed-article:7641467 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7641467 | pubmed:articleTitle | Interleukin-10 stimulates hematopoiesis in murine osteogenic stroma. | lld:pubmed |
| pubmed-article:7641467 | pubmed:affiliation | Department of Environment, Vlaamse Instelling voor Technologisch Onderzoek (VITO), Mol, Belgium. | lld:pubmed |
| pubmed-article:7641467 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7641467 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7641467 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7641467 | lld:pubmed |
