| pubmed-article:7636977 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7636977 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:7636977 | lifeskim:mentions | umls-concept:C0026473 | lld:lifeskim |
| pubmed-article:7636977 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:7636977 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:7636977 | lifeskim:mentions | umls-concept:C0108685 | lld:lifeskim |
| pubmed-article:7636977 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:7636977 | lifeskim:mentions | umls-concept:C0023978 | lld:lifeskim |
| pubmed-article:7636977 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:7636977 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7636977 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:7636977 | pubmed:dateCreated | 1995-9-14 | lld:pubmed |
| pubmed-article:7636977 | pubmed:abstractText | Three binding sites for C/EBP proteins are found in the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) (V. M. Tesmer, A. Rajadhyaksha, J. Babin, and M. Bina, Proc. Natl. Acad. Sci. USA 90:7298-7302, 1993). We have determined the functional role of C/EBP proteins and C/EBP sites in regulating transcription from the HIV-1 LTR in monocytes/macrophages. Inhibition of endogenous C/EBP proteins, using either an excess of C/EBP binding sites or a trans-dominant negative inhibitor, demonstrated that C/EBP proteins are required for basal and activated levels of HIV-1 LTR transcription in the promonocytic cell line U937. Northern (RNA) blots and binding assays showed that NF-IL6 is the only known C/EBP family member which is increased when U937 cells are activated. Mutational analyses of the HIV-1 LTR showed that one C/EBP site is required for normal LTR transcription both before and after cellular activation and that the two 3' C/EBP sites are functionally equivalent. However, transcription from crippled HIV-1 LTRs lacking C/EBP sites can still be induced following activation of U937 cells. Several models are suggested for how elevated NF-IL6 may participate in an autostimulatory loop involving HIV infection, macrophage activation, cytokine expression, and HIV replication. | lld:pubmed |
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| pubmed-article:7636977 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7636977 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636977 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7636977 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7636977 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7636977 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7636977 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:7636977 | pubmed:author | pubmed-author:CalameK LKL | lld:pubmed |
| pubmed-article:7636977 | pubmed:author | pubmed-author:HendersonA... | lld:pubmed |
| pubmed-article:7636977 | pubmed:author | pubmed-author:LiZ KZK | lld:pubmed |
| pubmed-article:7636977 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7636977 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:7636977 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7636977 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7636977 | pubmed:pagination | 5337-44 | lld:pubmed |
| pubmed-article:7636977 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
