| pubmed-article:7636303 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7636303 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:7636303 | lifeskim:mentions | umls-concept:C0023005 | lld:lifeskim |
| pubmed-article:7636303 | lifeskim:mentions | umls-concept:C0221920 | lld:lifeskim |
| pubmed-article:7636303 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:7636303 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:7636303 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:7636303 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:7636303 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7636303 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:7636303 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7636303 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7636303 | pubmed:dateCreated | 1995-9-12 | lld:pubmed |
| pubmed-article:7636303 | pubmed:abstractText | Activation of T lymphocytes by antigen-presenting cells requires the interaction of major histocompatibility complex/antigen complexes with the T-cell receptor as well as the binding of co-stimulatory molecules to receptors on T cells. Freshly isolated epidermal Langerhans cells (LC) do not display a significant number of co-stimulatory molecules. After short-term culture, LC express and then upregulate intercellular adhesion molecule-1 (ICAM-1) (CD54), leukocyte function-associated antigen (LFA)-3 (CD58), and B7-1 (CD80) accessory molecules and exhibit an enhanced antigen-presenting function. The present study examined the presence on human LC of the LFA-1 ligands ICAM-2 (CD102) and ICAM-3 (CD50) and their functional role in the activation of allogeneic T cells. Immunohistochemistry of skin sections and flow-cytometry analysis of freshly procured epidermal cell suspensions showed that LC (CD1a+ or HLA-DR+) expressed ICAM-3 but not ICAM-2. After 48-72-h culture in the presence of granulocyte/macrophage colony-stimulating factor, LC did not stain for ICAM-2 but expressed ICAM-3 at the same level as fresh cells. Incubation of both freshly isolated and cultured LC with monoclonal antibodies directed against ICAM-3 reduced T-cell proliferation (25-75% inhibition) in the primary allogeneic mixed leukocyte reaction assay; incubation of cultured LC with anti-ICAM-1 and anti-ICAM-3 synergistically reduced T-cell response. The results indicate that ICAM-3 is constitutively expressed and represents an important costimulatory molecule on freshly isolated LC but, in contrast to other accessory molecules, is not subjected to regulation during LC culture. | lld:pubmed |
| pubmed-article:7636303 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7636303 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636303 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7636303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636303 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636303 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7636303 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7636303 | pubmed:issn | 0022-202X | lld:pubmed |
| pubmed-article:7636303 | pubmed:author | pubmed-author:GiannettiAA | lld:pubmed |
| pubmed-article:7636303 | pubmed:author | pubmed-author:ZambrunoGG | lld:pubmed |
| pubmed-article:7636303 | pubmed:author | pubmed-author:CossarizzaAA | lld:pubmed |
| pubmed-article:7636303 | pubmed:author | pubmed-author:GirolomoniGG | lld:pubmed |
| pubmed-article:7636303 | pubmed:author | pubmed-author:ZacchiVV | lld:pubmed |
| pubmed-article:7636303 | pubmed:author | pubmed-author:OttaniDD | lld:pubmed |
| pubmed-article:7636303 | pubmed:author | pubmed-author:LuppiA MAM | lld:pubmed |
| pubmed-article:7636303 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7636303 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:7636303 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7636303 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7636303 | pubmed:pagination | 215-9 | lld:pubmed |
| pubmed-article:7636303 | pubmed:dateRevised | 2008-6-13 | lld:pubmed |
| pubmed-article:7636303 | pubmed:meshHeading | pubmed-meshheading:7636303-... | lld:pubmed |
| pubmed-article:7636303 | pubmed:meshHeading | pubmed-meshheading:7636303-... | lld:pubmed |
| pubmed-article:7636303 | pubmed:meshHeading | pubmed-meshheading:7636303-... | lld:pubmed |
| pubmed-article:7636303 | pubmed:meshHeading | pubmed-meshheading:7636303-... | lld:pubmed |
| pubmed-article:7636303 | pubmed:meshHeading | pubmed-meshheading:7636303-... | lld:pubmed |
| pubmed-article:7636303 | pubmed:meshHeading | pubmed-meshheading:7636303-... | lld:pubmed |
| pubmed-article:7636303 | pubmed:meshHeading | pubmed-meshheading:7636303-... | lld:pubmed |
| pubmed-article:7636303 | pubmed:meshHeading | pubmed-meshheading:7636303-... | lld:pubmed |
| pubmed-article:7636303 | pubmed:meshHeading | pubmed-meshheading:7636303-... | lld:pubmed |
| pubmed-article:7636303 | pubmed:meshHeading | pubmed-meshheading:7636303-... | lld:pubmed |
| pubmed-article:7636303 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7636303 | pubmed:articleTitle | Functional intercellular adhesion molecule-3 is expressed by freshly isolated epidermal Langerhans cells and is not regulated during culture. | lld:pubmed |
| pubmed-article:7636303 | pubmed:affiliation | Istituto Dermopatico dell'Immacolate, IRCCS, Rome, Italy. | lld:pubmed |
| pubmed-article:7636303 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7636303 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7636303 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7636303 | lld:pubmed |
