| pubmed-article:7628865 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7628865 | lifeskim:mentions | umls-concept:C0003864 | lld:lifeskim |
| pubmed-article:7628865 | lifeskim:mentions | umls-concept:C0032405 | lld:lifeskim |
| pubmed-article:7628865 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:7628865 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:7628865 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:7628865 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7628865 | pubmed:dateCreated | 1995-9-5 | lld:pubmed |
| pubmed-article:7628865 | pubmed:abstractText | Poly(ADPR) polymerase (PARP; EC 2.4.2.30) is a nuclear enzyme, which, when activated by oxygen- and nitrogen-radical-induced DNA strand breaks, transfers ADP ribose units to nuclear proteins and initiates apoptosis by depletion of cellular NAD and ATP pools. The present study investigates whether the oxidative stress-dependent activation of PARP plays a role in the etiopathogenesis of arthritis. The antiarthritic reactivity of the biogenic PARP inhibitor nicotinamide was tested in DBA/1 x B10A(4R) mice suffering from potassium peroxochromate-induced arthritis. Daily doses of 4 mmol/kg of NA suppressed the arthritis by 35% and inhibited the phagocytic generation of reactive oxygen species, which increases sixfold during the development of arthritis. The onset, progression, and remission of arthritis correlated positively to the phorbolester-activated respiratory burst of neutrophils and monocytes, and a dose-dependent inhibition of NADPH oxidase activity was determined with human phagocytes. Our data support the hypothesis that oxidative stress-induced alterations in cellular signal transduction pathways play a pivotal role in the development of arthritis, which can be suppressed by the simultaneous inhibition of poly(ADPR) polymerase and NADPH oxidase. | lld:pubmed |
| pubmed-article:7628865 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7628865 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7628865 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7628865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7628865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7628865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7628865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7628865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7628865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7628865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7628865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7628865 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7628865 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7628865 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7628865 | pubmed:issn | 0360-3997 | lld:pubmed |
| pubmed-article:7628865 | pubmed:author | pubmed-author:KrögerHH | lld:pubmed |
| pubmed-article:7628865 | pubmed:author | pubmed-author:KurpiszMM | lld:pubmed |
| pubmed-article:7628865 | pubmed:author | pubmed-author:MieselRR | lld:pubmed |
| pubmed-article:7628865 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7628865 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:7628865 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7628865 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7628865 | pubmed:pagination | 379-87 | lld:pubmed |
| pubmed-article:7628865 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:7628865 | pubmed:meshHeading | pubmed-meshheading:7628865-... | lld:pubmed |
| pubmed-article:7628865 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7628865 | pubmed:articleTitle | Modulation of inflammatory arthritis by inhibition of poly(ADP ribose) polymerase. | lld:pubmed |
| pubmed-article:7628865 | pubmed:affiliation | Department of Biochemistry, Deutsches RheumaForschungsZentrum, Berlin, Germany. | lld:pubmed |
| pubmed-article:7628865 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7628865 | lld:pubmed |
