| pubmed-article:7628019 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7628019 | lifeskim:mentions | umls-concept:C0024554 | lld:lifeskim |
| pubmed-article:7628019 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7628019 | lifeskim:mentions | umls-concept:C0039062 | lld:lifeskim |
| pubmed-article:7628019 | lifeskim:mentions | umls-concept:C0008633 | lld:lifeskim |
| pubmed-article:7628019 | lifeskim:mentions | umls-concept:C0025186 | lld:lifeskim |
| pubmed-article:7628019 | lifeskim:mentions | umls-concept:C0598501 | lld:lifeskim |
| pubmed-article:7628019 | lifeskim:mentions | umls-concept:C0205161 | lld:lifeskim |
| pubmed-article:7628019 | lifeskim:mentions | umls-concept:C1155661 | lld:lifeskim |
| pubmed-article:7628019 | lifeskim:mentions | umls-concept:C2350672 | lld:lifeskim |
| pubmed-article:7628019 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7628019 | pubmed:dateCreated | 1995-9-7 | lld:pubmed |
| pubmed-article:7628019 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7628019 | pubmed:abstractText | Using gene targeting in embryonic stem cells, we have derived mice with a null mutation in a DNA mismatch repair gene homolog, PMS2. We observed microsatellite instability in the male germline, in tail, and in tumor DNA of PMS2-deficient animals. We therefore conclude that PMS2 is involved in DNA mismatch repair in a variety of tissues. PMS2-deficient animals appear prone to sarcomas and lymphomas. PMS2-deficient males are infertile, producing only abnormal spermatozoa. Analysis of axial element and synaptonemal complex formation during prophase of meiosis I indicates abnormalities in chromosome synapsis. These observations suggest links among mismatch repair, genetic recombination, and chromosome synapsis in meiosis. | lld:pubmed |
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| pubmed-article:7628019 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7628019 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7628019 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7628019 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7628019 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:7628019 | pubmed:author | pubmed-author:YuJJ | lld:pubmed |
| pubmed-article:7628019 | pubmed:author | pubmed-author:FlavellR ARA | lld:pubmed |
| pubmed-article:7628019 | pubmed:author | pubmed-author:ElliottE AEA | lld:pubmed |
| pubmed-article:7628019 | pubmed:author | pubmed-author:WarrenGG | lld:pubmed |
| pubmed-article:7628019 | pubmed:author | pubmed-author:ArnheimNN | lld:pubmed |
| pubmed-article:7628019 | pubmed:author | pubmed-author:AshleyTT | lld:pubmed |
| pubmed-article:7628019 | pubmed:author | pubmed-author:LiskayR MRM | lld:pubmed |
| pubmed-article:7628019 | pubmed:author | pubmed-author:BakerS MSM | lld:pubmed |
| pubmed-article:7628019 | pubmed:author | pubmed-author:ZhangLL | lld:pubmed |
| pubmed-article:7628019 | pubmed:author | pubmed-author:BronnerC ECE | lld:pubmed |
| pubmed-article:7628019 | pubmed:author | pubmed-author:PlugA WAW | lld:pubmed |
| pubmed-article:7628019 | pubmed:author | pubmed-author:RobatzekMM | lld:pubmed |
| pubmed-article:7628019 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7628019 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:7628019 | pubmed:volume | 82 | lld:pubmed |
| pubmed-article:7628019 | pubmed:geneSymbol | PMS2 | lld:pubmed |
| pubmed-article:7628019 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7628019 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7628019 | pubmed:pagination | 309-19 | lld:pubmed |
| pubmed-article:7628019 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7628019 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7628019 | pubmed:articleTitle | Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis. | lld:pubmed |
| pubmed-article:7628019 | pubmed:affiliation | Department of Molecular and Medical Genetics, Oregon Health Sciences University, Portland 97201-3098, USA. | lld:pubmed |
| pubmed-article:7628019 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7628019 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7628019 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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