| pubmed-article:7626070 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7626070 | lifeskim:mentions | umls-concept:C0023903 | lld:lifeskim |
| pubmed-article:7626070 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:7626070 | lifeskim:mentions | umls-concept:C0041370 | lld:lifeskim |
| pubmed-article:7626070 | lifeskim:mentions | umls-concept:C1551336 | lld:lifeskim |
| pubmed-article:7626070 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:7626070 | lifeskim:mentions | umls-concept:C0060239 | lld:lifeskim |
| pubmed-article:7626070 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7626070 | pubmed:dateCreated | 1995-8-31 | lld:pubmed |
| pubmed-article:7626070 | pubmed:abstractText | Fe-NTA is a known renal carcinogen. However, little is known about its carcinogenic potential in liver. In this study we for the first time show that Fe-NTA is a potent hepatic tumor promoter. Fe-NTA administration induced dose dependently the hepatic ornithine decarboxylase (ODC) activity several folds as compared to its activity in the saline-treated rats. Similarly, hepatic DNA synthesis which is measured as [3H]thymidine incorporation in DNA is also increased following Fe-NTA treatment. The effects of Fe-NTA were similar to other tumor promoters not only with respect to inducing ODC activity and [3H]thymidine incorporation in DNA but also in depleting antioxidant armory of the tissue. Fe-NTA depleted levels of glutathione to about 35% of the saline-treated control and activities of antioxidant enzymes catalase, glutathione peroxidase, glutathione reductase and glucose 6-phosphate dehydrogenase decreased significantly (45-55% of saline-treated control). Concomitant with the depletion in antioxidant armory, Fe-NTA augmented hepatic microsomal lipid peroxidation more than three folds. The pretreatment of rats with antioxidants BHA or BHT diminished the observed effects of Fe-NTA. Our data indicate that Fe-NTA is a potent hepatic tumor promoter and acts through a mechanism involving oxidative stress. | lld:pubmed |
| pubmed-article:7626070 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7626070 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7626070 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7626070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7626070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7626070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7626070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7626070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7626070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7626070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7626070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7626070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7626070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7626070 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7626070 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7626070 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:7626070 | pubmed:author | pubmed-author:IqbalMM | lld:pubmed |
| pubmed-article:7626070 | pubmed:author | pubmed-author:AtharMM | lld:pubmed |
| pubmed-article:7626070 | pubmed:author | pubmed-author:GiriUU | lld:pubmed |
| pubmed-article:7626070 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7626070 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:7626070 | pubmed:volume | 212 | lld:pubmed |
| pubmed-article:7626070 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7626070 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7626070 | pubmed:pagination | 557-63 | lld:pubmed |
| pubmed-article:7626070 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:7626070 | pubmed:meshHeading | pubmed-meshheading:7626070-... | lld:pubmed |
| pubmed-article:7626070 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7626070 | pubmed:articleTitle | Ferric nitrilotriacetate (Fe-NTA) is a potent hepatic tumor promoter and acts through the generation of oxidative stress. | lld:pubmed |
| pubmed-article:7626070 | pubmed:affiliation | Department of Medical Elementology and Toxicology, Hamdard University, New Delhi, India. | lld:pubmed |
| pubmed-article:7626070 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7626070 | lld:pubmed |
