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pubmed-article:7625783pubmed:abstractTextIn summary, many isomeric analogs of ddNs of both D-related and L-related absolute stereochemistries have been synthesized and evaluated in vitro for their antiviral activities. A few of these compounds exhibit potent antiviral activity and, interestingly, belong to both the D and L families. The synthetic methodologies developed will allow accessibility to many more novel modified nucleosides. While some structure-activity relationships are emerging from this work, it is clear that these chiral isomeric nucleosides have opened a new chapter in the field of antiviral nucleosides.lld:pubmed
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pubmed-article:7625783pubmed:articleTitleAntiviral activities of isometric dideoxynucleosides of D- and L-related stereochemistry.lld:pubmed
pubmed-article:7625783pubmed:affiliationDepartment of Chemistry, University of Iowa, Iowa City 52242, USA.lld:pubmed
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