| pubmed-article:7606287 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7606287 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:7606287 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:7606287 | lifeskim:mentions | umls-concept:C0015780 | lld:lifeskim |
| pubmed-article:7606287 | lifeskim:mentions | umls-concept:C0014935 | lld:lifeskim |
| pubmed-article:7606287 | lifeskim:mentions | umls-concept:C0007320 | lld:lifeskim |
| pubmed-article:7606287 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:7606287 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7606287 | pubmed:dateCreated | 1995-8-17 | lld:pubmed |
| pubmed-article:7606287 | pubmed:abstractText | Seven female patients with mild to moderate dementia of the Alzheimer type (DAT) were treated with long-term, low-dose estrogen replacement therapy (ERT) over a period of 5-45 months. Five of the 7 patients were cases who had responded well to short-term ERT with 1.25 mg/day of conjugated equine estrogens (CEE) for 6 weeks. The 7 patients from 56 to 77 years of age received 0.625 mg/day of CEE for 21 days, followed by a pause of 7 days. A 28-day cycle of low-dose ERT was performed repeatedly. In 4 cases, these patients received 5 mg/day of medroxyprogesterone acetate (MPA) during the last 10-12 days of estrogen treatment. Therapeutic efficacy of estrogen was evaluated by psychometric assessments such as the Mini-Mental State Examination (MMSE) and the Hasegawa Dementia Scale (HDS) and a behavior rating scale of the Gottfries-Bråne-Steen geriatric rating scale (GBS). The MMSE and HDS evaluations were performed principally once in 2-4 weeks. In 4 out of the 7 patients, the MMSE and HDS scores were elevated above the pretreatment levels during ERT. The termination of ERT resulted in a decrease in both scores. Furthermore, the GBS scores and daily activities of the same 4 patients were improved during ERT. In these 4 patients cognitive functions were markedly improved throughout the treatment period, while the other 2 patients responded moderately well and another patient did not respond at all. These observations suggest that long-term, low-dose ERT improves cognitive functions, dementia symptoms and daily activities in women with mild to moderate DAT.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:7606287 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7606287 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7606287 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7606287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7606287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7606287 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7606287 | pubmed:issn | 1013-7424 | lld:pubmed |
| pubmed-article:7606287 | pubmed:author | pubmed-author:YaoiYY | lld:pubmed |
| pubmed-article:7606287 | pubmed:author | pubmed-author:HaginoNN | lld:pubmed |
| pubmed-article:7606287 | pubmed:author | pubmed-author:OhkuraTT | lld:pubmed |
| pubmed-article:7606287 | pubmed:author | pubmed-author:AkazawaKK | lld:pubmed |
| pubmed-article:7606287 | pubmed:author | pubmed-author:HamamotoMM | lld:pubmed |
| pubmed-article:7606287 | pubmed:author | pubmed-author:IsseKK | lld:pubmed |
| pubmed-article:7606287 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7606287 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:7606287 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7606287 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7606287 | pubmed:pagination | 99-107 | lld:pubmed |
| pubmed-article:7606287 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7606287 | pubmed:meshHeading | pubmed-meshheading:7606287-... | lld:pubmed |
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| pubmed-article:7606287 | pubmed:meshHeading | pubmed-meshheading:7606287-... | lld:pubmed |
| pubmed-article:7606287 | pubmed:meshHeading | pubmed-meshheading:7606287-... | lld:pubmed |
| pubmed-article:7606287 | pubmed:meshHeading | pubmed-meshheading:7606287-... | lld:pubmed |
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| pubmed-article:7606287 | pubmed:meshHeading | pubmed-meshheading:7606287-... | lld:pubmed |
| pubmed-article:7606287 | pubmed:meshHeading | pubmed-meshheading:7606287-... | lld:pubmed |
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| pubmed-article:7606287 | pubmed:meshHeading | pubmed-meshheading:7606287-... | lld:pubmed |
| pubmed-article:7606287 | pubmed:articleTitle | Long-term estrogen replacement therapy in female patients with dementia of the Alzheimer type: 7 case reports. | lld:pubmed |
| pubmed-article:7606287 | pubmed:affiliation | Department of Obstetrics and Gynecology, Koshigaya Hospital, Dokkyo University School of Medicine, Saitama, Japan. | lld:pubmed |
| pubmed-article:7606287 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7606287 | pubmed:publicationType | Case Reports | lld:pubmed |
| pubmed-article:7606287 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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