| pubmed-article:7603812 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7603812 | lifeskim:mentions | umls-concept:C0035870 | lld:lifeskim |
| pubmed-article:7603812 | lifeskim:mentions | umls-concept:C0021270 | lld:lifeskim |
| pubmed-article:7603812 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:7603812 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:7603812 | lifeskim:mentions | umls-concept:C0449943 | lld:lifeskim |
| pubmed-article:7603812 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7603812 | pubmed:dateCreated | 1995-8-7 | lld:pubmed |
| pubmed-article:7603812 | pubmed:abstractText | The objective of this study was to evaluate the efficacy of a live, attenuated bovine (strain WC3) x human (strain WI79, serotype G1) rotavirus reassortant (WI79-9) virus vaccine for prevention of symptomatic rotavirus gastroenteritis in infants. The study was a prospective, randomized, double-blind, placebo-controlled trial, conducted over a single rotavirus season in 325 infants who were 2 to 8 months old at enrollment. Subjects were randomized to receive either placebo or WI79-9 virus vaccine at 10(7.3) plaque-forming units in three oral doses each separated by 2 months. Subjects were followed for 7 days after each dose for occurrence of adverse events and during the subsequent winter for development of rotavirus gastroenteritis. Administration of WI79-9 virus vaccine was well-tolerated, and the rates of low grade fever after each dose were no higher in vaccine recipients (8 to 21%) than in placebo recipients (14 to 19%). The protective efficacy of the WI79-9 vaccine during a subsequent epidemic of predominantly serotype G1 rotavirus was 87.0% (95% confidence limits, 62.6 to 95.5%) against relatively severe rotavirus gastroenteritis (rotavirus gastroenteritis with a clinical severity score of > 8) and was 64.1% (95% confidence limits 35.9 to 79.9%) against all symptomatic rotavirus episodes. The WI79-9 vaccine was safe and effective in prevention of homotypic human rotavirus infection in infants. Further studies of reassortant vaccines based on the bovine WC3 rotavirus should be performed. | lld:pubmed |
| pubmed-article:7603812 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7603812 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7603812 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7603812 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7603812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7603812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7603812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7603812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7603812 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7603812 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7603812 | pubmed:issn | 0891-3668 | lld:pubmed |
| pubmed-article:7603812 | pubmed:author | pubmed-author:ClarkH FHF | lld:pubmed |
| pubmed-article:7603812 | pubmed:author | pubmed-author:ChristyCC | lld:pubmed |
| pubmed-article:7603812 | pubmed:author | pubmed-author:TreanorJ JJJ | lld:pubmed |
| pubmed-article:7603812 | pubmed:author | pubmed-author:GouveaVV | lld:pubmed |
| pubmed-article:7603812 | pubmed:author | pubmed-author:PichicheroMM | lld:pubmed |
| pubmed-article:7603812 | pubmed:author | pubmed-author:PalazzoSS | lld:pubmed |
| pubmed-article:7603812 | pubmed:author | pubmed-author:OffitPP | lld:pubmed |
| pubmed-article:7603812 | pubmed:author | pubmed-author:ShragerDD | lld:pubmed |
| pubmed-article:7603812 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7603812 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:7603812 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7603812 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7603812 | pubmed:pagination | 301-7 | lld:pubmed |
| pubmed-article:7603812 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7603812 | pubmed:meshHeading | pubmed-meshheading:7603812-... | lld:pubmed |
| pubmed-article:7603812 | pubmed:meshHeading | pubmed-meshheading:7603812-... | lld:pubmed |
| pubmed-article:7603812 | pubmed:meshHeading | pubmed-meshheading:7603812-... | lld:pubmed |
| pubmed-article:7603812 | pubmed:meshHeading | pubmed-meshheading:7603812-... | lld:pubmed |
| pubmed-article:7603812 | pubmed:meshHeading | pubmed-meshheading:7603812-... | lld:pubmed |
| pubmed-article:7603812 | pubmed:meshHeading | pubmed-meshheading:7603812-... | lld:pubmed |
| pubmed-article:7603812 | pubmed:meshHeading | pubmed-meshheading:7603812-... | lld:pubmed |
| pubmed-article:7603812 | pubmed:meshHeading | pubmed-meshheading:7603812-... | lld:pubmed |
| pubmed-article:7603812 | pubmed:meshHeading | pubmed-meshheading:7603812-... | lld:pubmed |
| pubmed-article:7603812 | pubmed:meshHeading | pubmed-meshheading:7603812-... | lld:pubmed |
| pubmed-article:7603812 | pubmed:meshHeading | pubmed-meshheading:7603812-... | lld:pubmed |
| pubmed-article:7603812 | pubmed:meshHeading | pubmed-meshheading:7603812-... | lld:pubmed |
| pubmed-article:7603812 | pubmed:meshHeading | pubmed-meshheading:7603812-... | lld:pubmed |
| pubmed-article:7603812 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7603812 | pubmed:articleTitle | Evaluation of the protective efficacy of a serotype 1 bovine-human rotavirus reassortant vaccine in infants. | lld:pubmed |
| pubmed-article:7603812 | pubmed:affiliation | Department of Medicine, University of Rochester, NY, USA. | lld:pubmed |
| pubmed-article:7603812 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7603812 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:7603812 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7603812 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:7603812 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7603812 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7603812 | lld:pubmed |
