| pubmed-article:7600971 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7600971 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7600971 | lifeskim:mentions | umls-concept:C0949649 | lld:lifeskim |
| pubmed-article:7600971 | lifeskim:mentions | umls-concept:C1511786 | lld:lifeskim |
| pubmed-article:7600971 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7600971 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7600971 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7600971 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7600971 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7600971 | pubmed:dateCreated | 1995-8-8 | lld:pubmed |
| pubmed-article:7600971 | pubmed:abstractText | The segmented mesoderm in vertebrates gives rise to a variety of cell types in the embryo including the axial skeleton and muscle. A number of transcription factors containing a paired domain (Pax proteins) are expressed in the segmented mesoderm during embryogenesis. These include Pax-3 and a closely related gene, Pax-7, both of which are expressed in the segmental plate and in the dermomyotome. In this paper, we show that signals from the notochord pattern the expression of Pax-3, Pax-7 and Pax-9 in somites and the subsequent differentiation of cell types that arise from the somitic mesoderm. We directly assess the role of the Pax-3 gene in the differentiation of cell types derived from the dermomyotome by analyzing the development of muscle in splotch mouse embryos which lack a functional Pax-3 gene. A population of Pax-3-expressing cells derived from the dermomyotome that normally migrate into the limb are absent in homozygous splotch embryos and, as a result, limb muscles are lost. No abnormalities were detected in the trunk musculature of splotch embryos indicating that Pax-3 is necessary for the development of the limb but not trunk muscle. | lld:pubmed |
| pubmed-article:7600971 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7600971 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7600971 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7600971 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7600971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7600971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7600971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7600971 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7600971 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7600971 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7600971 | pubmed:issn | 0950-1991 | lld:pubmed |
| pubmed-article:7600971 | pubmed:author | pubmed-author:GouldingMM | lld:pubmed |
| pubmed-article:7600971 | pubmed:author | pubmed-author:LumsdenAA | lld:pubmed |
| pubmed-article:7600971 | pubmed:author | pubmed-author:PaquetteA JAJ | lld:pubmed |
| pubmed-article:7600971 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7600971 | pubmed:volume | 120 | lld:pubmed |
| pubmed-article:7600971 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7600971 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7600971 | pubmed:pagination | 957-71 | lld:pubmed |
| pubmed-article:7600971 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7600971 | pubmed:meshHeading | pubmed-meshheading:7600971-... | lld:pubmed |
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| pubmed-article:7600971 | pubmed:meshHeading | pubmed-meshheading:7600971-... | lld:pubmed |
| pubmed-article:7600971 | pubmed:meshHeading | pubmed-meshheading:7600971-... | lld:pubmed |
| pubmed-article:7600971 | pubmed:meshHeading | pubmed-meshheading:7600971-... | lld:pubmed |
| pubmed-article:7600971 | pubmed:meshHeading | pubmed-meshheading:7600971-... | lld:pubmed |
| pubmed-article:7600971 | pubmed:meshHeading | pubmed-meshheading:7600971-... | lld:pubmed |
| pubmed-article:7600971 | pubmed:meshHeading | pubmed-meshheading:7600971-... | lld:pubmed |
| pubmed-article:7600971 | pubmed:meshHeading | pubmed-meshheading:7600971-... | lld:pubmed |
| pubmed-article:7600971 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7600971 | pubmed:articleTitle | Regulation of Pax-3 expression in the dermomyotome and its role in muscle development. | lld:pubmed |
| pubmed-article:7600971 | pubmed:affiliation | Molecular Neurobiology Laboratory, Salk Institute, La Jolla, CA 92037, USA. | lld:pubmed |
| pubmed-article:7600971 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7600971 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7600971 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:17928 | entrezgene:pubmed | pubmed-article:7600971 | lld:entrezgene |
| entrez-gene:18505 | entrezgene:pubmed | pubmed-article:7600971 | lld:entrezgene |
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