Linked Life Data

7595536

Source:http://linkedlifedata.com/resource/pubmed/id/7595536

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pubmed-article:7595536pubmed:abstractTextCultured cerebellar granule neurons maintained in depolarizing concentrations of K+ (25 mM) and then switched to physiological concentrations of K+ (5 mM) undergo apoptosis. We now report that activation of specific G proteins robustly and bidirectionally affects apotosis of cultured rat cerebellar granule neurons. Stimulation of Gs with cholera toxin completely blocks apoptosis induced by nondepolarizing concentrations of K+, whereas stimulation of Go/Gi with the wasp venom peptide mastoparan induces apoptosis of cerebellar granule neurons even in high (depolarizing) concentrations of K+. Moreover, pretreatment of cerebellar granule neurons with cholera toxin attenuates neuronal death induced by mastoparan. By contrast, pertussis toxin, cell-permeable analogues of cyclic AMP, and activators of protein kinase A do not affect apoptosis of cultured cerebellar granule neurons. These data suggest that G proteins may function as key switches for controlling the programmed death of mammalian neurons, especially in the developing CNS.lld:pubmed
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pubmed-article:7595536pubmed:dateRevised2005-11-17lld:pubmed
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pubmed-article:7595536pubmed:year1995lld:pubmed
pubmed-article:7595536pubmed:articleTitleActivation of G proteins bidirectionally affects apoptosis of cultured cerebellar granule neurons.lld:pubmed
pubmed-article:7595536pubmed:affiliationDepartment of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, USA.lld:pubmed
pubmed-article:7595536pubmed:publicationTypeJournal Articlelld:pubmed
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