| pubmed-article:7595491 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7595491 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7595491 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7595491 | lifeskim:mentions | umls-concept:C0010097 | lld:lifeskim |
| pubmed-article:7595491 | lifeskim:mentions | umls-concept:C0162512 | lld:lifeskim |
| pubmed-article:7595491 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:7595491 | lifeskim:mentions | umls-concept:C1657587 | lld:lifeskim |
| pubmed-article:7595491 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:7595491 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:7595491 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:7595491 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:7595491 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:7595491 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7595491 | pubmed:dateCreated | 1995-12-4 | lld:pubmed |
| pubmed-article:7595491 | pubmed:abstractText | We studied effects of Ca2+ in the incubation medium on [3H]dopamine ([3H]DA) uptake by rat striatal synaptosomes. Both the duration of the preincubation period with Ca2+ (0-30 min) and Ca2+ concentration (0-10 mM) in Krebs-Ringer medium affected [3H]DA uptake by the synaptosomes. The increase was maximal at a concentration of 1 mM Ca2+ after a 10-min preincubation (2.4 times larger than the uptake measured without preincubation), which reflected an increase in Vmax of the [3H]DA uptake process. On the other hand, [3H]DA uptake decreased rapidly after addition of ionomycin in the presence of 1 mM Ca2+. The Ca(2+)-dependent enhancement of the uptake was still maintained after washing synaptosomes with Ca(2+)-free medium following preincubation with 1 mM Ca2+. Protein kinase C inhibitors did not affect apparently Ca(2+)-dependent enhancement of the uptake, whereas 1(-)[N,O-bis(1,5-isoquinolinesulfonyl)-N-methyl-L- tyrosyl]-4-phenylpiperazine (KN-62; a Ca2+/calmodulin-dependent kinase II inhibitor) and wortmannin (a myosin light chain kinase inhibitor) significantly reduced it. Inhibitory effects of KN-62 and wortmannin appeared to be additive. N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride (W-7; a calmodulin antagonist) also remarkably inhibited the enhancement. These results suggest that Ca(2+)-dependent enhancement of [3H]DA uptake is mediated by activation of calmodulin-dependent protein kinases. | lld:pubmed |
| pubmed-article:7595491 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7595491 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7595491 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7595491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7595491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7595491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7595491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7595491 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7595491 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7595491 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7595491 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:7595491 | pubmed:author | pubmed-author:YamazakiYY | lld:pubmed |
| pubmed-article:7595491 | pubmed:author | pubmed-author:KiuchiYY | lld:pubmed |
| pubmed-article:7595491 | pubmed:author | pubmed-author:OguchiKK | lld:pubmed |
| pubmed-article:7595491 | pubmed:author | pubmed-author:UchikawaTT | lld:pubmed |
| pubmed-article:7595491 | pubmed:author | pubmed-author:YuriYY | lld:pubmed |
| pubmed-article:7595491 | pubmed:author | pubmed-author:YokomizoCC | lld:pubmed |
| pubmed-article:7595491 | pubmed:author | pubmed-author:NakachiNN | lld:pubmed |
| pubmed-article:7595491 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7595491 | pubmed:volume | 65 | lld:pubmed |
| pubmed-article:7595491 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7595491 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7595491 | pubmed:pagination | 2065-71 | lld:pubmed |
| pubmed-article:7595491 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:7595491 | pubmed:meshHeading | pubmed-meshheading:7595491-... | lld:pubmed |
| pubmed-article:7595491 | pubmed:meshHeading | pubmed-meshheading:7595491-... | lld:pubmed |
| pubmed-article:7595491 | pubmed:meshHeading | pubmed-meshheading:7595491-... | lld:pubmed |
| pubmed-article:7595491 | pubmed:meshHeading | pubmed-meshheading:7595491-... | lld:pubmed |
| pubmed-article:7595491 | pubmed:meshHeading | pubmed-meshheading:7595491-... | lld:pubmed |
| pubmed-article:7595491 | pubmed:meshHeading | pubmed-meshheading:7595491-... | lld:pubmed |
| pubmed-article:7595491 | pubmed:meshHeading | pubmed-meshheading:7595491-... | lld:pubmed |
| pubmed-article:7595491 | pubmed:meshHeading | pubmed-meshheading:7595491-... | lld:pubmed |
| pubmed-article:7595491 | pubmed:meshHeading | pubmed-meshheading:7595491-... | lld:pubmed |
| pubmed-article:7595491 | pubmed:meshHeading | pubmed-meshheading:7595491-... | lld:pubmed |
| pubmed-article:7595491 | pubmed:meshHeading | pubmed-meshheading:7595491-... | lld:pubmed |
| pubmed-article:7595491 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7595491 | pubmed:articleTitle | Ca(2+)-dependent enhancement of [3H]dopamine uptake in rat striatum: possible involvement of calmodulin-dependent kinases. | lld:pubmed |
| pubmed-article:7595491 | pubmed:affiliation | Department of Pharmacology, School of Medicine, Showa University, Tokyo, Japan. | lld:pubmed |
| pubmed-article:7595491 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7595491 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7595491 | lld:pubmed |
