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| pubmed-article:7594543 | lifeskim:mentions | umls-concept:C0014467 | lld:lifeskim |
| pubmed-article:7594543 | lifeskim:mentions | umls-concept:C0282552 | lld:lifeskim |
| pubmed-article:7594543 | lifeskim:mentions | umls-concept:C0524914 | lld:lifeskim |
| pubmed-article:7594543 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:7594543 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:7594543 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:7594543 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:7594543 | pubmed:dateCreated | 1995-12-28 | lld:pubmed |
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| pubmed-article:7594543 | pubmed:abstractText | beta or C-C chemokines including RANTES, MCP-3, MIP-1 alpha, and eotaxin have been implicated in the pathogenesis of eosinophilic inflammation. Two human beta chemokine receptors have been cloned and characterized: the MIP-1 alpha/RANTES receptor or C-C chemokine receptor 1 (CCR-1) and the MCP-1 receptor or C-C chemokine receptor 2 (CCR-2). However, no murine beta chemokine receptors have thus far been reported. Molecular cloning from mouse genomic DNA and cDNA libraries yielded two murine beta chemokine receptors with 79% and 65% sequence identity with human CCR-1, and 50% and 55% with human CCR-2. COS cells transiently transfected with the murine homologue of human CCR-1 bind murine MIP-1 alpha and human RANTES with Kds of 3.4 nM and 4.2 nM and murine MIP-1 beta with an EC50 of 8.9 nM. The other murine beta chemokine receptor, which we have designated murine CCR-3, also binds murine MIP-1 alpha. The mRNAs for both receptors are expressed in eosinophils from IL-5 transgenic mice. The level of murine CCR-3 mRNA in these mouse eosinophils exceeds that of CCR-1 mRNA and approaches actin levels. Murine MIP-1 alpha was found to be a potent chemoattractant for murine eosinophils. Our findings suggest that the murine MIP-1 alpha ligand/receptor system is an important mediator of murine eosinophil trafficking. | lld:pubmed |
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| pubmed-article:7594543 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7594543 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7594543 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7594543 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:7594543 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7594543 | pubmed:author | pubmed-author:GerardCC | lld:pubmed |
| pubmed-article:7594543 | pubmed:author | pubmed-author:GerardNN | lld:pubmed |
| pubmed-article:7594543 | pubmed:author | pubmed-author:SaalRR | lld:pubmed |
| pubmed-article:7594543 | pubmed:author | pubmed-author:LusterA DAD | lld:pubmed |
| pubmed-article:7594543 | pubmed:author | pubmed-author:RothenbergM... | lld:pubmed |
| pubmed-article:7594543 | pubmed:author | pubmed-author:BozicC RCR | lld:pubmed |
| pubmed-article:7594543 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7594543 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7594543 | pubmed:volume | 155 | lld:pubmed |
| pubmed-article:7594543 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7594543 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7594543 | pubmed:pagination | 5299-305 | lld:pubmed |
| pubmed-article:7594543 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7594543 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7594543 | pubmed:articleTitle | Molecular characterization of two murine eosinophil beta chemokine receptors. | lld:pubmed |
| pubmed-article:7594543 | pubmed:affiliation | Department of Medicine, Brigham and Women's Hospital, Beth Israel Hospital, Boston, MA, USA. | lld:pubmed |
| pubmed-article:7594543 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7594543 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7594543 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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