| pubmed-article:75941 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:75941 | lifeskim:mentions | umls-concept:C1511362 | lld:lifeskim |
| pubmed-article:75941 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:75941 | lifeskim:mentions | umls-concept:C0085732 | lld:lifeskim |
| pubmed-article:75941 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:75941 | lifeskim:mentions | umls-concept:C0205470 | lld:lifeskim |
| pubmed-article:75941 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:75941 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:75941 | pubmed:dateCreated | 1978-5-17 | lld:pubmed |
| pubmed-article:75941 | pubmed:abstractText | The lipopolysaccharide (LPS)-protein complex extracted from the cell wall of Escherichia coli K235 by the butanol-water technique has been shown to evoke a mitogenic response in bone marrow-derived (B) lymphocytes from the C3H/HeJ mouse strain. These mice are resistant to the effects of LPS extracted with phenol. Therefore, the ability of butanol-extracted LPS to modulate a spectrum of C3H/HeJ B-cell functions was investigated. Both butanol-extracted (LPS-B) and phenol-extracted (LPS-P) LPS preparations activated responder C3H/St spleen cell cultures to polyclonal antibody production, while only LPS-B activated C3H/HeJ spleen cells. Both LPS-P and LPS-B acted as adjuvants when injected after aggregated human gamma globulin (HGG) in C3H/St mice, but neither preparation was effective as a adjuvant in C3H/HeJ mice. LPS-P injected with deaggregated HGG (tolerogen) into LPS-sensitive mice has been shown previously to inhibit the induction of tolerance HGG. In the present studies, it was shown that LPS-B, but not LPs-p, was able to inhibit tolerance induction to HGG in the C3H/HeJ, whereas both preparations were effective in the C3H/St. LPS has also been shown to bypass tolerant T cells in LPS-sensitive mice late in tolerance to HGG at a time when B cells are responsive. However, in the C3H/HeJ, neither LPS-B nor LPS-P was capable of this function. The responsiveness of these B cells to HGG was demonstrated in transfer experiments. Thus, in the C3H/HeJ, LPS-B stimulates mitogenesis, polyclonal B-cell activation, and inhibition of tolerance induction, but cannot act as an effective adjuvant or as a bypass mechanism to activate B cells in the presence of tolerant T cells. The explanation for this pattern of responses may be attributable to yet another cellular defect in the C3H/HeJ mouse. | lld:pubmed |
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| pubmed-article:75941 | pubmed:language | eng | lld:pubmed |
| pubmed-article:75941 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:75941 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:75941 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:75941 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:75941 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:75941 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:75941 | pubmed:author | pubmed-author:WeigleW OWO | lld:pubmed |
| pubmed-article:75941 | pubmed:author | pubmed-author:ParksD EDE | lld:pubmed |
| pubmed-article:75941 | pubmed:author | pubmed-author:GoodmanM GMG | lld:pubmed |
| pubmed-article:75941 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:75941 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:75941 | pubmed:volume | 147 | lld:pubmed |
| pubmed-article:75941 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:75941 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:75941 | pubmed:pagination | 800-13 | lld:pubmed |
| pubmed-article:75941 | pubmed:dateRevised | 2010-9-1 | lld:pubmed |
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| pubmed-article:75941 | pubmed:meshHeading | pubmed-meshheading:75941-Mi... | lld:pubmed |
| pubmed-article:75941 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:75941 | pubmed:articleTitle | Immunologic responsiveness of the C3H/HeJ mouse: differential ability of butanol-extracted lipopolysaccharide (LPS) to evoke LPS-mediated effects. | lld:pubmed |
| pubmed-article:75941 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:75941 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
