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pubmed-article:7589519pubmed:abstractTextCu/Zn-Superoxide dismutase activity (Cu/Zn-SOD) was studied in liver from 3- and 24-month-old rat. A significant decrease of enzyme activity in liver of the aged rat was found. Various amino acid residues and protein carbonyl groups (CO) were measured in purified young and old enzyme. It was found that the 'old' enzyme had one histidine fewer and higher CO content than the 'young' Cu/Zn-SOD. Inactivation 'in vitro' of purified commercial bovine erythrocyte Cu/Zn-SOD led to a decrease in the enzymatic activity, an increase in the CO and one histidine residue modified. A similar behavior between aging and oxidation was suggested.lld:pubmed
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pubmed-article:7589519pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:7589519pubmed:articleTitleChanges in the histidine residues of Cu/Zn superoxide dismutase during aging.lld:pubmed
pubmed-article:7589519pubmed:affiliationDepartamento de Bioquimica, Bromatologia y Toxicologia, Facultad de Farmacia, Universidad de Sevilla, Spain.lld:pubmed
pubmed-article:7589519pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7589519pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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