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| pubmed-article:7589143 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7589143 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
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| pubmed-article:7589143 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:7589143 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:7589143 | lifeskim:mentions | umls-concept:C0104998 | lld:lifeskim |
| pubmed-article:7589143 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7589143 | lifeskim:mentions | umls-concept:C1413243 | lld:lifeskim |
| pubmed-article:7589143 | lifeskim:mentions | umls-concept:C1366561 | lld:lifeskim |
| pubmed-article:7589143 | lifeskim:mentions | umls-concept:C1705431 | lld:lifeskim |
| pubmed-article:7589143 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7589143 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7589143 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7589143 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:7589143 | pubmed:dateCreated | 1995-11-28 | lld:pubmed |
| pubmed-article:7589143 | pubmed:abstractText | Most of the immunosuppressive effects of interleukin-10 (IL-10) are related to functional inhibition of antigen-presenting cells (APC). Herein, we investigate the influence of recombinant (r)IL-10 on human dendritic cells (DC) purified from peripheral blood of healthy volunteers. First, we found that rIL-10 inhibited in a dose-dependent manner the proliferative responses as well as the production of IL-2 and interferon-gamma (IFN-gamma) in mixed lymphocyte reaction (MLR) between purified T cells and DC. This rIL-10 effect could be attributed to a direct effect on DC, as DC preincubated with rIL-10 were found to be deficient in the induction of alloreactive T cells even when anti-IL-10 neutralizing mAb was added at the time of MLR. Flow cytometric analysis indicated that rIL-10 did not modify the expression of ICAM-1 (CD54) and B7-1 (CD80), but decreased HLA-DR and B7-2 (CD86) expression at the DC surface. We conclude that the inhibitory effect of rIL-10 on primary alloreactive T cell responses involves down-regulation of class II MHC and B7-2 expression at the DC surface. | lld:pubmed |
| pubmed-article:7589143 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7589143 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7589143 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7589143 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7589143 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7589143 | pubmed:issn | 0014-2980 | lld:pubmed |
| pubmed-article:7589143 | pubmed:author | pubmed-author:GoldmanMM | lld:pubmed |
| pubmed-article:7589143 | pubmed:author | pubmed-author:ESODAE C JEC | lld:pubmed |
| pubmed-article:7589143 | pubmed:author | pubmed-author:DelvilleJ PJP | lld:pubmed |
| pubmed-article:7589143 | pubmed:author | pubmed-author:PiérardGG | lld:pubmed |
| pubmed-article:7589143 | pubmed:author | pubmed-author:DelvauxAA | lld:pubmed |
| pubmed-article:7589143 | pubmed:author | pubmed-author:WillemsFF | lld:pubmed |
| pubmed-article:7589143 | pubmed:author | pubmed-author:BuelensCC | lld:pubmed |
| pubmed-article:7589143 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7589143 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:7589143 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7589143 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7589143 | pubmed:pagination | 2668-72 | lld:pubmed |
| pubmed-article:7589143 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7589143 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7589143 | pubmed:articleTitle | Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells. | lld:pubmed |
| pubmed-article:7589143 | pubmed:affiliation | Department of Immunology, Hôpital Erasme, Université Libre de Bruxelles, Belgium. | lld:pubmed |
| pubmed-article:7589143 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7589143 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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