| pubmed-article:7583576 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7583576 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:7583576 | lifeskim:mentions | umls-concept:C0001554 | lld:lifeskim |
| pubmed-article:7583576 | lifeskim:mentions | umls-concept:C0034493 | lld:lifeskim |
| pubmed-article:7583576 | lifeskim:mentions | umls-concept:C0003842 | lld:lifeskim |
| pubmed-article:7583576 | lifeskim:mentions | umls-concept:C0205400 | lld:lifeskim |
| pubmed-article:7583576 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7583576 | lifeskim:mentions | umls-concept:C0441127 | lld:lifeskim |
| pubmed-article:7583576 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:7583576 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:7583576 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:7583576 | pubmed:dateCreated | 1995-12-18 | lld:pubmed |
| pubmed-article:7583576 | pubmed:abstractText | The in vivo effect of transforming growth factor-beta 1 (TGF-beta 1) was studied in a model system in which arterial intimal thickening was induced by injury of rabbit arteries with a balloon catheter (BCI). Intimal area and its ratio to medial area in carotid arteries after BCI were significantly higher in rabbits treated with 10 micrograms/kg TGF-beta 1 and 10 mg/kg aspirin i.v. QD (TGF-beta 1 group) than in those treated with 10 mg/kg aspirin i.v. QD only (control group). Intimal cell numbers in the TGF-beta 1 and control groups were not significantly different from each other, but matrix volume in the intimal layer was significantly higher in the TGF-beta 1 group. By immunohistochemical and Northern blot analyses, the fibronectin content in carotid intimal and medial layers was greater in the TGF-beta 1 group compared with that in the control group. Thus, in intimal thickenings induced by BCI. TGF-beta 1 mainly enhanced the formation of matrix containing fibronectin. Moreover, the mRNAs of TGF-beta 1 and type II receptors were detected in carotid arteries 7 and 14 days after, but not before, BCI. Thus, TGF-beta 1 influences the process of intimal thickening induced by BCI through a receptor-mediated mechanism in vivo. The significance of this fact is discussed in relation to the development of atherosclerosis. | lld:pubmed |
| pubmed-article:7583576 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7583576 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7583576 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7583576 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7583576 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7583576 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7583576 | pubmed:issn | 1079-5642 | lld:pubmed |
| pubmed-article:7583576 | pubmed:author | pubmed-author:TakahashiKK | lld:pubmed |
| pubmed-article:7583576 | pubmed:author | pubmed-author:SaitoYY | lld:pubmed |
| pubmed-article:7583576 | pubmed:author | pubmed-author:KanzakiTT | lld:pubmed |
| pubmed-article:7583576 | pubmed:author | pubmed-author:UedaMM | lld:pubmed |
| pubmed-article:7583576 | pubmed:author | pubmed-author:TamuraKK | lld:pubmed |
| pubmed-article:7583576 | pubmed:author | pubmed-author:MorisakiNN | lld:pubmed |
| pubmed-article:7583576 | pubmed:author | pubmed-author:AkikusaBB | lld:pubmed |
| pubmed-article:7583576 | pubmed:author | pubmed-author:OohashiHH | lld:pubmed |
| pubmed-article:7583576 | pubmed:author | pubmed-author:KasayukiNN | lld:pubmed |
| pubmed-article:7583576 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7583576 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:7583576 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7583576 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7583576 | pubmed:pagination | 1951-7 | lld:pubmed |
| pubmed-article:7583576 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:7583576 | pubmed:meshHeading | pubmed-meshheading:7583576-... | lld:pubmed |
| pubmed-article:7583576 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7583576 | pubmed:articleTitle | In vivo effect of TGF- beta 1. Enhanced intimal thickening by administration of TGF- beta 1 in rabbit arteries injured with a balloon catheter. | lld:pubmed |
| pubmed-article:7583576 | pubmed:affiliation | Second Department of Internal Medicine, School of Medicine, Chiba University, Japan. | lld:pubmed |
| pubmed-article:7583576 | pubmed:publicationType | Journal Article | lld:pubmed |
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