| pubmed-article:7582502 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7582502 | lifeskim:mentions | umls-concept:C0729531 | lld:lifeskim |
| pubmed-article:7582502 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7582502 | lifeskim:mentions | umls-concept:C0999699 | lld:lifeskim |
| pubmed-article:7582502 | lifeskim:mentions | umls-concept:C0040578 | lld:lifeskim |
| pubmed-article:7582502 | lifeskim:mentions | umls-concept:C0039241 | lld:lifeskim |
| pubmed-article:7582502 | lifeskim:mentions | umls-concept:C0279023 | lld:lifeskim |
| pubmed-article:7582502 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7582502 | pubmed:dateCreated | 1995-12-15 | lld:pubmed |
| pubmed-article:7582502 | pubmed:abstractText | 1. We investigated whether virus-induced airway hyperresponsiveness in guinea-pigs could be modulated by pretreatment with capsaicin and whether viral respiratory infections could potentiate ovalbumin-aerosol-induced tracheal hyperresponsiveness. 2. Animals were inoculated intratracheally with bovine parainfluenza-3 virus or control medium 7 days after treatment with capsaicin (50 mg kg-1, s.c.). Four days after inoculation, tracheal contractions were measured to increasing concentrations of substance P, histamine and the cholinoceptor agonist, arecoline. 3. In tracheae from virus-infected guinea-pigs, contractions in response to substance P, histamine and arecoline were significantly enhanced (P < 0.01) by 144%, 46% and 77%, respectively. Capsaicin pretreatment inhibited the hyperresponsiveness to substance P partly (62%) and to histamine and arecoline completely. 4. In another series of experiments animals were first sensitized with ovalbumin (20 mg kg-1, i.p.). After 14 days animals were exposed to either saline or ovalbumin aerosols for 8 days. After 4 aerosol exposures (4 days) animals were inoculated with either parainfluenza-3 virus or control medium. One day after the last ovalbumin aerosol, tracheal contraction in response to increasing concentrations of substance P, histamine and arecoline was measured. 5. Tracheae from ovalbumin-aerosol-exposed control inoculated animals showed a similar degree of airway hyperresponsiveness to saline-aerosol-exposed virus-treated guinea-pigs. Virus inoculation of ovalbumin-treated animals significantly potentiated the tracheal contractions to substance P compared to either of the treatments alone. The contractions in response to histamine and arecoline were only slightly enhanced. 6. In conclusion, sensory nerves and/or tachykinins are involved in virus-induced airway hyperresponsivenessin guinea-pigs and viral respiratory infections can potentiate the increase in tracheal responsiveness to bronchoconstrictor agonists after ovalbumin exposure. | lld:pubmed |
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| pubmed-article:7582502 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7582502 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7582502 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7582502 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7582502 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7582502 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7582502 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:7582502 | pubmed:author | pubmed-author:NijkampF PFP | lld:pubmed |
| pubmed-article:7582502 | pubmed:author | pubmed-author:FolkertsGG | lld:pubmed |
| pubmed-article:7582502 | pubmed:author | pubmed-author:van der... | lld:pubmed |
| pubmed-article:7582502 | pubmed:author | pubmed-author:LadeniusA RAR | lld:pubmed |
| pubmed-article:7582502 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7582502 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:7582502 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7582502 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7582502 | pubmed:pagination | 1048-52 | lld:pubmed |
| pubmed-article:7582502 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7582502 | pubmed:meshHeading | pubmed-meshheading:7582502-... | lld:pubmed |
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| pubmed-article:7582502 | pubmed:meshHeading | pubmed-meshheading:7582502-... | lld:pubmed |
| pubmed-article:7582502 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7582502 | pubmed:articleTitle | Potentiation by viral respiratory infection of ovalbumin-induced guinea-pig tracheal hyperresponsiveness: role for tachykinins. | lld:pubmed |
| pubmed-article:7582502 | pubmed:affiliation | Department of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands. | lld:pubmed |
| pubmed-article:7582502 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7582502 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
