| pubmed-article:7578430 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7578430 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7578430 | lifeskim:mentions | umls-concept:C0032405 | lld:lifeskim |
| pubmed-article:7578430 | lifeskim:mentions | umls-concept:C1155874 | lld:lifeskim |
| pubmed-article:7578430 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:7578430 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7578430 | pubmed:dateCreated | 1995-12-14 | lld:pubmed |
| pubmed-article:7578430 | pubmed:abstractText | A nuclear poly(ADP-ribose) polymerase (PARP) is activated by gamma-irradiation and consequently synthesizes poly(ADP-ribose) by binding to DNA strand-breaks. This property suggests that PARP is a DNA strand-break-signal generator. Meanwhile, the cell-cycle arrest occurs in G1 and G2 phases following gamma-irradiation. We found that PARP inhibitors including 3-aminobenzamide (3-AB) suppressed G1 arrest and enhanced G2 arrest following gamma-irradiation. These observations suggested that PARP is critical for the induction of G1 arrest and is also involved in the regulation of G2 arrest. Furthermore, the effects of 3-AB on the G1-arrest signal-transduction pathway were also studied. We found that p53 stabilization following gamma-irradiation was not inhibited but the p53-responsive transient increases of WAF1/CIP1/p21 and MDM-2 mRNA were suppressed by 3-AB. Therefore, it is suggested that PARP participates in G1-arrest signal-transduction pathway through the modulation of WAF1/CIP1/p21 and MDM-2 mRNA expression. | lld:pubmed |
| pubmed-article:7578430 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7578430 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7578430 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7578430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7578430 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7578430 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7578430 | pubmed:issn | 0300-9084 | lld:pubmed |
| pubmed-article:7578430 | pubmed:author | pubmed-author:SugimuraTT | lld:pubmed |
| pubmed-article:7578430 | pubmed:author | pubmed-author:WakabayashiKK | lld:pubmed |
| pubmed-article:7578430 | pubmed:author | pubmed-author:MasutaniMM | lld:pubmed |
| pubmed-article:7578430 | pubmed:author | pubmed-author:NozakiTT | lld:pubmed |
| pubmed-article:7578430 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7578430 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:7578430 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7578430 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7578430 | pubmed:pagination | 462-5 | lld:pubmed |
| pubmed-article:7578430 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7578430 | pubmed:meshHeading | pubmed-meshheading:7578430-... | lld:pubmed |
| pubmed-article:7578430 | pubmed:meshHeading | pubmed-meshheading:7578430-... | lld:pubmed |
| pubmed-article:7578430 | pubmed:meshHeading | pubmed-meshheading:7578430-... | lld:pubmed |
| pubmed-article:7578430 | pubmed:meshHeading | pubmed-meshheading:7578430-... | lld:pubmed |
| pubmed-article:7578430 | pubmed:meshHeading | pubmed-meshheading:7578430-... | lld:pubmed |
| pubmed-article:7578430 | pubmed:meshHeading | pubmed-meshheading:7578430-... | lld:pubmed |
| pubmed-article:7578430 | pubmed:meshHeading | pubmed-meshheading:7578430-... | lld:pubmed |
| pubmed-article:7578430 | pubmed:meshHeading | pubmed-meshheading:7578430-... | lld:pubmed |
| pubmed-article:7578430 | pubmed:meshHeading | pubmed-meshheading:7578430-... | lld:pubmed |
| pubmed-article:7578430 | pubmed:meshHeading | pubmed-meshheading:7578430-... | lld:pubmed |
| pubmed-article:7578430 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7578430 | pubmed:articleTitle | Role of poly(ADP-ribose) polymerase in cell-cycle checkpoint mechanisms following gamma-irradiation. | lld:pubmed |
| pubmed-article:7578430 | pubmed:affiliation | Biochemistry Division, National Cancer Center Research Institute, Tokyo, Japan. | lld:pubmed |
| pubmed-article:7578430 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7578430 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:7578430 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7578430 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7578430 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7578430 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7578430 | lld:pubmed |
