| pubmed-article:7577472 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7577472 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7577472 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7577472 | lifeskim:mentions | umls-concept:C0038880 | lld:lifeskim |
| pubmed-article:7577472 | lifeskim:mentions | umls-concept:C0035412 | lld:lifeskim |
| pubmed-article:7577472 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:7577472 | lifeskim:mentions | umls-concept:C0596138 | lld:lifeskim |
| pubmed-article:7577472 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7577472 | lifeskim:mentions | umls-concept:C0181687 | lld:lifeskim |
| pubmed-article:7577472 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:7577472 | lifeskim:mentions | umls-concept:C1313915 | lld:lifeskim |
| pubmed-article:7577472 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7577472 | pubmed:dateCreated | 1995-12-26 | lld:pubmed |
| pubmed-article:7577472 | pubmed:abstractText | Three human rhabdomyosarcoma cell lines were used to investigate the presence of autocrine loops based on the production of insulin-like growth factor (IGF)-II, basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF)/transforming growth factor (TGF)-alpha and of their corresponding receptors, and whether these loops affect cell proliferation and myogenic differentiation. Two cell lines, RD/18 and CCA, deriving from tumours of the embryonal histotype, showed the presence of both growth factors and receptors which make possible three different autocrine loops, while the alveolar RMZ-RC2 cell line lacked that based on the EGF receptor. Culture of rhabdomyosarcoma cells in the presence of specific blocking antibodies, directed to a component of single autocrine loops, inhibited cell proliferation (up to 50%), without inducing myogenic differentiation. Suramin, a drug which non-selectively interferes with the binding of growth factors to their cellular receptors, was used to block all the autocrine loops simultaneously. In CCA and RMZ-RC2 cells suramin was able to induce a significant increase (up to 3-fold) in the proportion of myosin-positive cells over control cultures. Therefore rhabdomyosarcoma cells of embryonal and alveolar histotype can show a redundancy of growth-sustaining autocrine loops. Suramin could interfere with them by acting on both growth inhibition and induction of myogenic differentiation. | lld:pubmed |
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| pubmed-article:7577472 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7577472 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7577472 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7577472 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7577472 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7577472 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7577472 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:7577472 | pubmed:author | pubmed-author:NicolettiGG | lld:pubmed |
| pubmed-article:7577472 | pubmed:author | pubmed-author:NanniPP | lld:pubmed |
| pubmed-article:7577472 | pubmed:author | pubmed-author:De GiovanniCC | lld:pubmed |
| pubmed-article:7577472 | pubmed:author | pubmed-author:LolliniP LPL | lld:pubmed |
| pubmed-article:7577472 | pubmed:author | pubmed-author:LanduzziLL | lld:pubmed |
| pubmed-article:7577472 | pubmed:author | pubmed-author:ColomboM PMP | lld:pubmed |
| pubmed-article:7577472 | pubmed:author | pubmed-author:MelaniCC | lld:pubmed |
| pubmed-article:7577472 | pubmed:author | pubmed-author:FrabettiFF | lld:pubmed |
| pubmed-article:7577472 | pubmed:author | pubmed-author:GriffoniCC | lld:pubmed |
| pubmed-article:7577472 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7577472 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:7577472 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7577472 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7577472 | pubmed:pagination | 1224-9 | lld:pubmed |
| pubmed-article:7577472 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7577472 | pubmed:meshHeading | pubmed-meshheading:7577472-... | lld:pubmed |
| pubmed-article:7577472 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7577472 | pubmed:articleTitle | Redundancy of autocrine loops in human rhabdomyosarcoma cells: induction of differentiation by suramin. | lld:pubmed |
| pubmed-article:7577472 | pubmed:affiliation | Istituto di Cancerologia, Università di Bologna, Italy. | lld:pubmed |
| pubmed-article:7577472 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7577472 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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