| pubmed-article:7575574 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7575574 | lifeskim:mentions | umls-concept:C0033164 | lld:lifeskim |
| pubmed-article:7575574 | lifeskim:mentions | umls-concept:C0005595 | lld:lifeskim |
| pubmed-article:7575574 | lifeskim:mentions | umls-concept:C0024660 | lld:lifeskim |
| pubmed-article:7575574 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:7575574 | lifeskim:mentions | umls-concept:C0039290 | lld:lifeskim |
| pubmed-article:7575574 | lifeskim:mentions | umls-concept:C1148611 | lld:lifeskim |
| pubmed-article:7575574 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:7575574 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:7575574 | lifeskim:mentions | umls-concept:C0597551 | lld:lifeskim |
| pubmed-article:7575574 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7575574 | pubmed:dateCreated | 1995-11-2 | lld:pubmed |
| pubmed-article:7575574 | pubmed:abstractText | Using CD spectroscopy we have investigated the effect of Cu2+ on the secondary structure of synthetic peptides Octa4 and Hexa4 corresponding to tetra-repeats of the octapeptide of mammalian PrP and the hexapeptide of chicken PrP. In addition, fluorescence spectroscopy was used to estimate the dissociation constants (Kd), of Cu2+ binding by both peptides. Both peptides exhibited unusual CD spectra, complicated by the high proportion of aromatic residues, revealing little secondary structure in aqueous solution. Addition of Cu2+ to Hexa4 induced an increase in random coil to resemble Octa4. The fluorescence of both peptides was quenched by Cu2+ and this was used to calculate Kd's of 6.7 microM for Octa4 and 4.5 microM for Hexa4. Other divalent cations showed lesser effects on the fluorescence of the peptides. | lld:pubmed |
| pubmed-article:7575574 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7575574 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7575574 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7575574 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7575574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7575574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7575574 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7575574 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7575574 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:7575574 | pubmed:author | pubmed-author:McDermottJ... | lld:pubmed |
| pubmed-article:7575574 | pubmed:author | pubmed-author:CanerJ EJE | lld:pubmed |
| pubmed-article:7575574 | pubmed:author | pubmed-author:LakeyJ HJH | lld:pubmed |
| pubmed-article:7575574 | pubmed:author | pubmed-author:HornshawM PMP | lld:pubmed |
| pubmed-article:7575574 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7575574 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:7575574 | pubmed:volume | 214 | lld:pubmed |
| pubmed-article:7575574 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7575574 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7575574 | pubmed:pagination | 993-9 | lld:pubmed |
| pubmed-article:7575574 | pubmed:dateRevised | 2010-8-25 | lld:pubmed |
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| pubmed-article:7575574 | pubmed:meshHeading | pubmed-meshheading:7575574-... | lld:pubmed |
| pubmed-article:7575574 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7575574 | pubmed:articleTitle | Copper binding to the N-terminal tandem repeat region of mammalian and avian prion protein: structural studies using synthetic peptides. | lld:pubmed |
| pubmed-article:7575574 | pubmed:affiliation | MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom. | lld:pubmed |
| pubmed-article:7575574 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7575574 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7575574 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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