pubmed-article:7570983 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:7570983 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:7570983 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
pubmed-article:7570983 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
pubmed-article:7570983 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
pubmed-article:7570983 | lifeskim:mentions | umls-concept:C0010592 | lld:lifeskim |
pubmed-article:7570983 | lifeskim:mentions | umls-concept:C1515406 | lld:lifeskim |
pubmed-article:7570983 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
pubmed-article:7570983 | pubmed:issue | 7 | lld:pubmed |
pubmed-article:7570983 | pubmed:dateCreated | 1995-11-22 | lld:pubmed |
pubmed-article:7570983 | pubmed:abstractText | Scarring, fibrosis, and immunosuppression occurs with chronic cyclosporine (CsA) administration. We postulated that CsA may induce transforming growth factor (TGF)-beta 1 secretion from human T lymphocytes, a cytokine with immunoregulatory effects that has been implicated in the pathogenesis of wound healing and scarring. TGF-beta 1 was measured in serum-free supernatants harvested from T lymphocytes stimulated in the presence of CsA by a specific sandwich ELISA. CsA (10-1000 ng/ml) enhanced TGF-beta 1 secretion by approximately 40-80% in a dose-dependent manner. Increased TGF-beta 1 secretion in the presence of CsA was accompanied by a 2- to 4-fold increase in TGF-beta 1 mRNA levels due to both enhancement of its nuclear transcription as well as prolongation of TGF-beta 1 mRNA half-life. To determine whether the increase in TGF-beta 1 secretion was also accompanied by a concomitant change in its receptor, TGF-beta 1 receptor expression was analyzed by cross-linking of radioiodinated TGF-beta 1. Unactivated T lymphocytes expressed both a 105-kDa and a 65-kDa TGF-beta receptor. Upon stimulation, a transient increase in receptor density was seen at 12 hr, followed by a decline at later time points. Cells treated with CsA exhibited at least 2-fold higher levels of TGF-beta receptors in a dose-dependent manner. Thus, CsA enhances the production of TGF-beta 1 protein as well as the expression of its receptor in activated T lymphocytes. Enhanced TGF-beta 1 production and binding may contribute to the immunosuppressive and fibrosis-promoting effects of CsA therapy. | lld:pubmed |
pubmed-article:7570983 | pubmed:language | eng | lld:pubmed |
pubmed-article:7570983 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7570983 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:7570983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7570983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7570983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7570983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7570983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:7570983 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:7570983 | pubmed:month | Oct | lld:pubmed |
pubmed-article:7570983 | pubmed:issn | 0041-1337 | lld:pubmed |
pubmed-article:7570983 | pubmed:author | pubmed-author:BalowJ EJE | lld:pubmed |
pubmed-article:7570983 | pubmed:author | pubmed-author:AhujaS SSS | lld:pubmed |
pubmed-article:7570983 | pubmed:author | pubmed-author:DanielpourDD | lld:pubmed |
pubmed-article:7570983 | pubmed:author | pubmed-author:BoumpasD TDT | lld:pubmed |
pubmed-article:7570983 | pubmed:author | pubmed-author:ShrivastavSS | lld:pubmed |
pubmed-article:7570983 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:7570983 | pubmed:day | 15 | lld:pubmed |
pubmed-article:7570983 | pubmed:volume | 60 | lld:pubmed |
pubmed-article:7570983 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:7570983 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:7570983 | pubmed:pagination | 718-23 | lld:pubmed |
pubmed-article:7570983 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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pubmed-article:7570983 | pubmed:year | 1995 | lld:pubmed |
pubmed-article:7570983 | pubmed:articleTitle | Regulation of transforming growth factor-beta 1 and its receptor by cyclosporine in human T lymphocytes. | lld:pubmed |
pubmed-article:7570983 | pubmed:affiliation | Kidney Disease Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. | lld:pubmed |
pubmed-article:7570983 | pubmed:publicationType | Journal Article | lld:pubmed |
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