| pubmed-article:7567447 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7567447 | lifeskim:mentions | umls-concept:C0558295 | lld:lifeskim |
| pubmed-article:7567447 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:7567447 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:7567447 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:7567447 | lifeskim:mentions | umls-concept:C1513315 | lld:lifeskim |
| pubmed-article:7567447 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:7567447 | pubmed:dateCreated | 1995-11-6 | lld:pubmed |
| pubmed-article:7567447 | pubmed:abstractText | We have examined the interaction of distamycin, netropsin, Hoechst 33258 and berenil, which are AT-selective minor groove-binding ligands, with synthetic DNA fragments containing different arrangements of AT base pairs by DNase I footprinting. For fragments which contain multiple blocks of (A/T)4 quantitative DNase I footprinting reveals that AATT and AAAA are much better binding sites than TTAA and TATA. Hoechst 33258 shows that greatest discrimination between these sites with a 50-fold difference in affinity between AATT and TATA. Alone amongst these ligands, Hoechst 33258 binds to AATT better than AAAA. These differences in binding to the various AT-tracts are interpreted in terms of variations in DNA minor groove width and suggest that TpA steps within an AT-tract decrease the affinity of these ligands. The behaviour of each site also depends on the flanking sequences; adjacent pyrimidine-purine steps cause a decrease in affinity. The precise ranking order for the various binding sites is not the same for each ligand. | lld:pubmed |
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| pubmed-article:7567447 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7567447 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7567447 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7567447 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7567447 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:7567447 | pubmed:author | pubmed-author:BrownP MPM | lld:pubmed |
| pubmed-article:7567447 | pubmed:author | pubmed-author:OGORODNITSKAI... | lld:pubmed |
| pubmed-article:7567447 | pubmed:author | pubmed-author:Abu-DayaAA | lld:pubmed |
| pubmed-article:7567447 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7567447 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:7567447 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:7567447 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7567447 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7567447 | pubmed:pagination | 3385-92 | lld:pubmed |
| pubmed-article:7567447 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7567447 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7567447 | pubmed:articleTitle | DNA sequence preferences of several AT-selective minor groove binding ligands. | lld:pubmed |
| pubmed-article:7567447 | pubmed:affiliation | Department of Physiology and Pharmacology, University of Southampton, UK. | lld:pubmed |
| pubmed-article:7567447 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7567447 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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