| pubmed-article:7565672 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7565672 | lifeskim:mentions | umls-concept:C0027923 | lld:lifeskim |
| pubmed-article:7565672 | lifeskim:mentions | umls-concept:C0002520 | lld:lifeskim |
| pubmed-article:7565672 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:7565672 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:7565672 | lifeskim:mentions | umls-concept:C1519618 | lld:lifeskim |
| pubmed-article:7565672 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:7565672 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:7565672 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:7565672 | lifeskim:mentions | umls-concept:C0470187 | lld:lifeskim |
| pubmed-article:7565672 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:7565672 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:7565672 | pubmed:dateCreated | 1995-10-25 | lld:pubmed |
| pubmed-article:7565672 | pubmed:abstractText | We examined the regulation of Neurospora crassa arg-2 and cpc-1 in response to amino acid availability.arg-2 encodes the small subunit of arginine-specific carbamoyl phosphate synthetase; it is subject to unique negative regulation by Arg and is positively regulated in response to limitation for many different amino acids through a mechanism known as cross-pathway control. cpc-1 specifies a transcriptional activator important for crosspathway control. Expression of these genes was compared with that of the cytochrome oxidase subunit V gene, cox-5. Analyses of mRNA levels, polypeptide pulse-labeling results, and the distribution of mRNA in polysomes indicated that Arg-specific negative regulation of arg-2 affected the levels of both arg-2 mRNA and arg-2 mRNA translation. Negative translational effects on arg-2 and positive translational effects on cpc-1 were apparent soon after cells were provided with exogenous Arg. In cells limited for His, increased expression of arg-2 and cpc-1, and decreased expression of cox-5, also had translational and transcriptional components. The arg-2 and cpc-1 transcripts contain upstream open reading frames (uORFs), as do their Saccharomyces cerevisiae homologs CPA1 and GCN4. We examined the regulation of arg-2-lacZ reporter genes containing or lacking the uORF start codon; the capacity for arg-2 uORF translation appeared critical for controlling gene expression. | lld:pubmed |
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| pubmed-article:7565672 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7565672 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7565672 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7565672 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7565672 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7565672 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:7565672 | pubmed:author | pubmed-author:FreitagMM | lld:pubmed |
| pubmed-article:7565672 | pubmed:author | pubmed-author:LuxSS | lld:pubmed |
| pubmed-article:7565672 | pubmed:author | pubmed-author:SachsM SMS | lld:pubmed |
| pubmed-article:7565672 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7565672 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:7565672 | pubmed:geneSymbol | cpc-1 | lld:pubmed |
| pubmed-article:7565672 | pubmed:geneSymbol | arg-2 | lld:pubmed |
| pubmed-article:7565672 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7565672 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7565672 | pubmed:pagination | 5235-45 | lld:pubmed |
| pubmed-article:7565672 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7565672 | pubmed:meshHeading | pubmed-meshheading:7565672-... | lld:pubmed |
| pubmed-article:7565672 | pubmed:meshHeading | pubmed-meshheading:7565672-... | lld:pubmed |
