Polymorphism of glutathione S-transferase M1 and lung cancer risk among African-Americans and Caucasians in Los Angeles County, California.

Source:http://linkedlifedata.com/resource/pubmed/id/7563171

J. Natl. Cancer Inst. 1995 Aug 16 87 16 1246-53

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Authors

Cooper J, Idle JR, London SJ, Daly AK, Carpenter CL, Navidi WC

Affiliation

Division of Occupational and Environmental Medicine, University of Southern California School of Medicine, Los Angeles 90033, USA.

Abstract

Glutathione S-transferase M1 (GSTM1) is active in the detoxication of a number of carcinogens, including polyaromatic hydrocarbons, such as those present in cigarette smoke. In about 30%-55% of individuals, depending on the ethnic group, there is a virtual absence of GSTM1 enzyme activity due to deletion of both copies of the GSTM1 gene (GSTM1 null genotype). This genetic polymorphism of the GSTM1 gene locus has been proposed as a risk factor for lung cancer. However, results across studies are inconsistent.

PMID
7563171

Publication types

Research Support, U.S. Gov't, P.H.S.; Research Support, Non-U.S. Gov't