| pubmed-article:7552993 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7552993 | lifeskim:mentions | umls-concept:C0242299 | lld:lifeskim |
| pubmed-article:7552993 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7552993 | lifeskim:mentions | umls-concept:C1367453 | lld:lifeskim |
| pubmed-article:7552993 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:7552993 | lifeskim:mentions | umls-concept:C0034840 | lld:lifeskim |
| pubmed-article:7552993 | lifeskim:mentions | umls-concept:C2347338 | lld:lifeskim |
| pubmed-article:7552993 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7552993 | pubmed:dateCreated | 1995-10-31 | lld:pubmed |
| pubmed-article:7552993 | pubmed:abstractText | The transcription factor Nur77, an orphan member of the nuclear hormone receptor superfamily, is highly expressed during T cell receptor-signaled apoptosis, suggesting a possible role for Nur77 in negative selection. We examined this by generating two sets of transgenic mice. In one set of mice, a dominant-negative Nur77 mutant is constitutively expressed and the other in which wild-type Nur77 protein is constitutively expressed in developing thymocytes. We report that inhibition of endogenous Nur77 by the dominant-negative mutant perturbed T cell development and inhibited antigen-induced negative selection in F5T cell receptor transgenic mice. Constitutive expression of wild-type Nur77 protein induced apoptosis in developing thymocytes, resulting in a decreased number of thymocytes and mature T cells. Together, these data support a role for Nur77 in the downstream signaling events in antigen-induced negative selection. | lld:pubmed |
| pubmed-article:7552993 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7552993 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7552993 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7552993 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7552993 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7552993 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7552993 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7552993 | pubmed:issn | 1074-7613 | lld:pubmed |
| pubmed-article:7552993 | pubmed:author | pubmed-author:CadiNN | lld:pubmed |
| pubmed-article:7552993 | pubmed:author | pubmed-author:ChanF KFK | lld:pubmed |
| pubmed-article:7552993 | pubmed:author | pubmed-author:WinotoAA | lld:pubmed |
| pubmed-article:7552993 | pubmed:author | pubmed-author:CalnanB JBJ | lld:pubmed |
| pubmed-article:7552993 | pubmed:author | pubmed-author:SzychowskiSS | lld:pubmed |
| pubmed-article:7552993 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7552993 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:7552993 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7552993 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7552993 | pubmed:pagination | 273-82 | lld:pubmed |
| pubmed-article:7552993 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7552993 | pubmed:meshHeading | pubmed-meshheading:7552993-... | lld:pubmed |
| pubmed-article:7552993 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7552993 | pubmed:articleTitle | A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. | lld:pubmed |
| pubmed-article:7552993 | pubmed:affiliation | Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA. | lld:pubmed |
| pubmed-article:7552993 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7552993 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7552993 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7552993 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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