| pubmed-article:7543449 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C0001721 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:7543449 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:7543449 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7543449 | pubmed:dateCreated | 1995-9-11 | lld:pubmed |
| pubmed-article:7543449 | pubmed:abstractText | The peptidic nature of the male (H-Y) antigen, a model minor histocompatibility antigen in H-2b mice, has recently been demonstrated. In this study we show that the H-Y peptide, which is recognized by PM-1, a Db-restricted cytotoxic T-lymphocyte (CTL) clone, is absent in male H-2d spleen cells but present in male H-2d spleen cells that also express a transgenic Db molecule under its endogenous promoter. This result indicates that both the H-Y and the Db gene products are essential and sufficient for production of the Db-restricted H-Y peptide. By comparing the ability of the PM-1 clone and bulk CTL generated in a secondary mixed lymphocyte culture to recognize H-Y peptidic material eluted from affinity-purified Db molecules and separated by reversed-phase high-performance liquid chromatography (HPLC), we provide evidence that there is an immunodominant H-Y epitope that is presented by the Db molecule. Furthermore, the presentation of this epitope is not affected by a mutation in the alpha 3 domain of Db (asp227 to lys227), which abrogates CD8 binding, since similar amounts of H-Y peptide were eluted from affinity-purified wild-type or mutant Db molecules. However, the generation of the H-Y epitope is dependent on the presence of beta 2-microglobulin, since it is absent in male H-2b mice that lack a functional beta 2-microglobulin gene. The implications of these findings on T-cell development are discussed. | lld:pubmed |
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| pubmed-article:7543449 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7543449 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7543449 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7543449 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7543449 | pubmed:month | May | lld:pubmed |
| pubmed-article:7543449 | pubmed:issn | 0019-2805 | lld:pubmed |
| pubmed-article:7543449 | pubmed:author | pubmed-author:TehH SHS | lld:pubmed |
| pubmed-article:7543449 | pubmed:author | pubmed-author:TamS WSW | lld:pubmed |
| pubmed-article:7543449 | pubmed:author | pubmed-author:KilleenNN | lld:pubmed |
| pubmed-article:7543449 | pubmed:author | pubmed-author:DutzJ PJP | lld:pubmed |
| pubmed-article:7543449 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7543449 | pubmed:volume | 85 | lld:pubmed |
| pubmed-article:7543449 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7543449 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7543449 | pubmed:pagination | 74-81 | lld:pubmed |
| pubmed-article:7543449 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7543449 | pubmed:meshHeading | pubmed-meshheading:7543449-... | lld:pubmed |
| pubmed-article:7543449 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7543449 | pubmed:articleTitle | A mutation in the alpha 3 domain of Db that abrogates CD8 binding does not affect presentation of an immunodominant H-Y peptide. | lld:pubmed |
| pubmed-article:7543449 | pubmed:affiliation | Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada. | lld:pubmed |
| pubmed-article:7543449 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7543449 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:83772 | entrezgene:pubmed | pubmed-article:7543449 | lld:entrezgene |
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