| pubmed-article:7543095 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7543095 | lifeskim:mentions | umls-concept:C0029341 | lld:lifeskim |
| pubmed-article:7543095 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:7543095 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:7543095 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:7543095 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7543095 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7543095 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:7543095 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:7543095 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:7543095 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7543095 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7543095 | pubmed:issue | 30 | lld:pubmed |
| pubmed-article:7543095 | pubmed:dateCreated | 1995-9-5 | lld:pubmed |
| pubmed-article:7543095 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7543095 | pubmed:abstractText | We previously found that the level of Fas, a cell surface receptor for an apoptosis signal, increases at the mRNA level in influenza virus-infected HeLa cells prior to their death by apoptosis. Here we investigated the mechanism of activation of the Fas-encoding gene expression upon influenza virus infection. Nucleotide sequences for the binding of nuclear factor for interleukin-6 expression (NF-IL6), also known as CCAAT/enhancer-binding protein beta, were repeated 8 times in the 5'-end region of the human FAS gene, spanning from -1360 to +320. This region directed the expression of a downstream marker gene when introduced into HeLa cells and the activity of the FAS gene promoter was stimulated about 2-fold upon influenza virus infection. Gene expression driven by the FAS promoter was activated when human NF-IL6 was overproduced in a DNA when human NF-IL6 was overproduced in a DNA co-transfection study. Moreover, the DNA-binding activity of NF-IL6 increased after infection with the virus, whereas the amount of NF-IL6 seemed unchanged. The results suggest that NF-IL6 is activated upon influenza virus infection through post-translational modification and that the modified factor stimulates the transcription of the human FAS gene. | lld:pubmed |
| pubmed-article:7543095 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7543095 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7543095 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7543095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7543095 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7543095 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7543095 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7543095 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7543095 | pubmed:author | pubmed-author:KobayashiNN | lld:pubmed |
| pubmed-article:7543095 | pubmed:author | pubmed-author:TakizawaTT | lld:pubmed |
| pubmed-article:7543095 | pubmed:author | pubmed-author:NakanishiYY | lld:pubmed |
| pubmed-article:7543095 | pubmed:author | pubmed-author:MatsumuraMM | lld:pubmed |
| pubmed-article:7543095 | pubmed:author | pubmed-author:WadaNN | lld:pubmed |
| pubmed-article:7543095 | pubmed:author | pubmed-author:OhbaYY | lld:pubmed |
| pubmed-article:7543095 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7543095 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:7543095 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:7543095 | pubmed:geneSymbol | Fas | lld:pubmed |
| pubmed-article:7543095 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7543095 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7543095 | pubmed:pagination | 18007-12 | lld:pubmed |
| pubmed-article:7543095 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:7543095 | pubmed:meshHeading | pubmed-meshheading:7543095-... | lld:pubmed |
| pubmed-article:7543095 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7543095 | pubmed:articleTitle | Transcription stimulation of the Fas-encoding gene by nuclear factor for interleukin-6 expression upon influenza virus infection. | lld:pubmed |
| pubmed-article:7543095 | pubmed:affiliation | Graduate School of Natural Science and Technology, Kanazawa University, Ishikawa, Japan. | lld:pubmed |
| pubmed-article:7543095 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7543095 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:355 | entrezgene:pubmed | pubmed-article:7543095 | lld:entrezgene |
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