| pubmed-article:7540977 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7540977 | lifeskim:mentions | umls-concept:C0870134 | lld:lifeskim |
| pubmed-article:7540977 | lifeskim:mentions | umls-concept:C0018957 | lld:lifeskim |
| pubmed-article:7540977 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:7540977 | lifeskim:mentions | umls-concept:C0028778 | lld:lifeskim |
| pubmed-article:7540977 | lifeskim:mentions | umls-concept:C1148673 | lld:lifeskim |
| pubmed-article:7540977 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:7540977 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:7540977 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:7540977 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:7540977 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:7540977 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:7540977 | pubmed:dateCreated | 1995-8-3 | lld:pubmed |
| pubmed-article:7540977 | pubmed:abstractText | The E26 avian leukaemia virus encodes a fusion oncoprotein consisting of truncated versions of the c-Myb and c-Ets-1 transcription factors. When used to infect embryonic chicken haematopoietic cells two types of self-renewing progenitors are obtained, namely myeloblasts and 'MEPs' (Myb-Ets progenitors). In earlier work we have shown that myeloblasts transformed by the ts21 mutant of E26, which has a lesion in v-Myb, can be induced to differentiate into macrophages following shift to the non-permissive temperature. Here we show that the ts21 v-Myb is temperature sensitive for DNA binding in band shift experiments and that its inactivation in transformed MEPs induces their maturation into thrombocytes. The MEP transforming capacity of v-Myb is not confined to its fusion with v-Ets, as it is also seen with a virus that co-expresses tsMyb with v-ErbB. As with wild-type E26-transformed MEPs, ts21-transformed MEPs are multipotent, differentiating into eosinophils and myeloblasts following treatment with 12-O-tetradecanoylphorbol-13-acetate. In addition, ts21-transformed myeloblasts differentiate into macrophages when shifted to the non-permissive temperature. This shows that v-Myb blocks haematopoietic differentiation at two distinct stages. In contrast, v-Ets inactivation in MEPs transformed by a ts E26 mutant with a lesion in the corresponding oncoprotein leads to their differentiation into erythrocytes, myeloblasts and probably eosinophils. These data show that the two domains of Myb-Ets selectively affect decision making processes in different types and stages of haematopoietic cells. | lld:pubmed |
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| pubmed-article:7540977 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7540977 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7540977 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7540977 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7540977 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7540977 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:7540977 | pubmed:author | pubmed-author:SmithGG | lld:pubmed |
| pubmed-article:7540977 | pubmed:author | pubmed-author:GradJJ | lld:pubmed |
| pubmed-article:7540977 | pubmed:author | pubmed-author:FramptonJJ | lld:pubmed |
| pubmed-article:7540977 | pubmed:author | pubmed-author:PhilipAA | lld:pubmed |
| pubmed-article:7540977 | pubmed:author | pubmed-author:McNagnyKK | lld:pubmed |
| pubmed-article:7540977 | pubmed:author | pubmed-author:SiewekeMM | lld:pubmed |
| pubmed-article:7540977 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7540977 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7540977 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:7540977 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7540977 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7540977 | pubmed:pagination | 2866-75 | lld:pubmed |
| pubmed-article:7540977 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
