| pubmed-article:7537691 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7537691 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7537691 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7537691 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:7537691 | lifeskim:mentions | umls-concept:C0026249 | lld:lifeskim |
| pubmed-article:7537691 | lifeskim:mentions | umls-concept:C0079349 | lld:lifeskim |
| pubmed-article:7537691 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7537691 | pubmed:dateCreated | 1995-6-5 | lld:pubmed |
| pubmed-article:7537691 | pubmed:abstractText | We have found that in the primary culture of rat hepatocytes, the potent mitogenic activity of native FGF-1 is independent of heparin. The well-established characteristic of FGF-1 as a heparin-dependent mitogen is confirmed by human umbilical vein endothelial cells using the same preparation of FGF-1. Cross-linking experiments reveal that binding of FGF-1 to the hepatocyte cell surface receptors can be accomplished in the absence of exogenous heparin, in contrast to human endothelial cells for which it remains as a limiting factor. For both cell types, however, it is demonstrated that either endogenous or exogenous heparan sulfate/heparin moieties are essential for FGF-1 to establish receptor binding and mitogen action. Thus, the results suggest that hepatocytes harbor cell surface heparan sulfate moieties that are fully capable of utilizing FGF-1 in the environment. These results raise the possibility that FGF-1 is of differential potency for different cell types according to the nature and/or quantity of cell surface heparan sulfate moieties in vivo. | lld:pubmed |
| pubmed-article:7537691 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7537691 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7537691 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7537691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7537691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7537691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7537691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7537691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7537691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7537691 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7537691 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7537691 | pubmed:month | May | lld:pubmed |
| pubmed-article:7537691 | pubmed:issn | 0014-4827 | lld:pubmed |
| pubmed-article:7537691 | pubmed:author | pubmed-author:MitsuiYY | lld:pubmed |
| pubmed-article:7537691 | pubmed:author | pubmed-author:SuzukiMM | lld:pubmed |
| pubmed-article:7537691 | pubmed:author | pubmed-author:TanahashiTT | lld:pubmed |
| pubmed-article:7537691 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7537691 | pubmed:volume | 218 | lld:pubmed |
| pubmed-article:7537691 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7537691 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7537691 | pubmed:pagination | 233-40 | lld:pubmed |
| pubmed-article:7537691 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7537691 | pubmed:meshHeading | pubmed-meshheading:7537691-... | lld:pubmed |
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| pubmed-article:7537691 | pubmed:meshHeading | pubmed-meshheading:7537691-... | lld:pubmed |
| pubmed-article:7537691 | pubmed:meshHeading | pubmed-meshheading:7537691-... | lld:pubmed |
| pubmed-article:7537691 | pubmed:meshHeading | pubmed-meshheading:7537691-... | lld:pubmed |
| pubmed-article:7537691 | pubmed:meshHeading | pubmed-meshheading:7537691-... | lld:pubmed |
| pubmed-article:7537691 | pubmed:meshHeading | pubmed-meshheading:7537691-... | lld:pubmed |
| pubmed-article:7537691 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7537691 | pubmed:articleTitle | FGF-1 is a heparin-independent mitogen for rat hepatocytes. | lld:pubmed |
| pubmed-article:7537691 | pubmed:affiliation | Cell Biology Laboratory, National Institute of Bioscience and Human Technology, Ibaraki, Japan. | lld:pubmed |
| pubmed-article:7537691 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7537691 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
