| pubmed-article:7536901 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7536901 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:7536901 | lifeskim:mentions | umls-concept:C0030946 | lld:lifeskim |
| pubmed-article:7536901 | lifeskim:mentions | umls-concept:C0020746 | lld:lifeskim |
| pubmed-article:7536901 | lifeskim:mentions | umls-concept:C1366479 | lld:lifeskim |
| pubmed-article:7536901 | lifeskim:mentions | umls-concept:C1539477 | lld:lifeskim |
| pubmed-article:7536901 | lifeskim:mentions | umls-concept:C0280697 | lld:lifeskim |
| pubmed-article:7536901 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:7536901 | pubmed:issue | 6526 | lld:pubmed |
| pubmed-article:7536901 | pubmed:dateCreated | 1995-5-25 | lld:pubmed |
| pubmed-article:7536901 | pubmed:abstractText | The Fas/APO-1 receptor is one of the major regulators of apoptosis. We report here that Fas/APO-1-mediated apoptosis requires the activation of a new class of cysteine proteases, including interleukin-1 beta-converting enzyme (ICE), which are homologous to the product of the Caenorhabditis elegans cell-death gene ced-3 (refs 11, 12). Triggering of Fas/APO-1 rapidly stimulated the proteolytic activity of ICE. Overexpression of ICE, achieved by electroporation and microinjection, strongly potentiated Fas/APO-1-mediated cell death. In addition, inhibition of ICE activity by protease inhibitors, as well as by transient expression of the pox virus-derived serpin inhibitor CrmA or an antisense ICE construct, substantially suppressed Fas/APO-1-triggered cell death. We conclude that activation of ICE or an ICE-related protease is a critical event in Fas/APO-1-mediated cell death. | lld:pubmed |
| pubmed-article:7536901 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7536901 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7536901 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7536901 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7536901 | pubmed:month | May | lld:pubmed |
| pubmed-article:7536901 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:7536901 | pubmed:author | pubmed-author:SchenkHH | lld:pubmed |
| pubmed-article:7536901 | pubmed:author | pubmed-author:KrammerP HPH | lld:pubmed |
| pubmed-article:7536901 | pubmed:author | pubmed-author:FiersWW | lld:pubmed |
| pubmed-article:7536901 | pubmed:author | pubmed-author:DrögeWW | lld:pubmed |
| pubmed-article:7536901 | pubmed:author | pubmed-author:BaeuerleP APA | lld:pubmed |
| pubmed-article:7536901 | pubmed:author | pubmed-author:Schulze-Ostho... | lld:pubmed |
| pubmed-article:7536901 | pubmed:author | pubmed-author:Van de... | lld:pubmed |
| pubmed-article:7536901 | pubmed:author | pubmed-author:PenningL CLC | lld:pubmed |
| pubmed-article:7536901 | pubmed:author | pubmed-author:LosMM | lld:pubmed |
| pubmed-article:7536901 | pubmed:author | pubmed-author:WestendorpMM | lld:pubmed |
| pubmed-article:7536901 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7536901 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:7536901 | pubmed:volume | 375 | lld:pubmed |
| pubmed-article:7536901 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7536901 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7536901 | pubmed:pagination | 81-3 | lld:pubmed |
| pubmed-article:7536901 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7536901 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7536901 | pubmed:articleTitle | Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. | lld:pubmed |
| pubmed-article:7536901 | pubmed:affiliation | Division of Immunochemistry, German Cancer Research Center, Heidelberg. | lld:pubmed |
| pubmed-article:7536901 | pubmed:publicationType | Journal Article | lld:pubmed |
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