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pubmed-article:7536101pubmed:abstractTextThe soma membrane of the fast coxal depressor (Df) motoneurone of the cockroach, Periplaneta americana possesses a population of acetylcholine receptors which respond to both nicotinic and muscarinic ligands. Activation of these 'mixed' acetylcholine receptors by McN-A-343 or oxotremorine results in the generation of an inward current at potentials positive to - 40 mV. A large proportion of the outward current induced by membrane depolarization in Df somata is due to a calcium-activated potassium conductance (IKCa) which shows a characteristic N-shape voltage-dependence. This N-shape of the membrane current-voltage relationship is suppressed by McN-A-343 or oxotremorine indicating that the agonist-induced inward current is due to a reduction in IKCa.lld:pubmed
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pubmed-article:7536101pubmed:authorpubmed-author:PitmanR MRMlld:pubmed
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pubmed-article:7536101pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:7536101pubmed:year1995lld:pubmed
pubmed-article:7536101pubmed:articleTitleMuscarinic agonists modulate calcium-dependent outward currents in an identified insect motoneurone.lld:pubmed
pubmed-article:7536101pubmed:affiliationGatty Marine Laboratory, School of Biological and Medical Sciences, University of St. Andrews, Fife, UK.lld:pubmed
pubmed-article:7536101pubmed:publicationTypeJournal Articlelld:pubmed