| pubmed-article:7534710 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7534710 | lifeskim:mentions | umls-concept:C1518999 | lld:lifeskim |
| pubmed-article:7534710 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7534710 | pubmed:dateCreated | 1995-4-26 | lld:pubmed |
| pubmed-article:7534710 | pubmed:abstractText | We evaluated the expansion capacity of untreated and 5-fluorouracil (5-FU)-resistant peripheral blood stem cells (PBSC) after 7-day incubation with interleukin-1 (IL-1) plus IL-3 plus stem cell factor (SCF) or with medium alone. We found a significant increase in the proportion of CD34+ cells in the PBSC fraction resistant to 25 micrograms/mL 5-FU after 7-day incubation with IL-1 plus IL-3 plus SCF as compared with the untreated fraction (p = 0.011). We also showed that 5-FU-resistant PBSC have a greater capacity for expansion of IL-1/IL-3/SCF-responsive immature progenitors (p = 0.05), amplification of IL-3 plus GM-CSF responsive progenitors (p = 0.01), and production of committed single growth factor-responsive (granulocyte-macrophage colony-stimulating factor [GM-CSF]) precursors (p = 0.01) than the untreated PBSC. The expansion of all types of progenitors and CD34+ cells was only observed after 7-day incubation with IL-1 plus IL-3 plus SCF. These results suggest that PBSC contain a primitive stem cell population with an enhanced expansion capacity that is identified by 5-FU resistance. As these cells can be expanded in vitro, they may then be suitable for a number of clinical applications. | lld:pubmed |
| pubmed-article:7534710 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534710 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7534710 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534710 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7534710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7534710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534710 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7534710 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7534710 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7534710 | pubmed:issn | 0301-472X | lld:pubmed |
| pubmed-article:7534710 | pubmed:author | pubmed-author:ReiffersJJ | lld:pubmed |
| pubmed-article:7534710 | pubmed:author | pubmed-author:BarboyNN | lld:pubmed |
| pubmed-article:7534710 | pubmed:author | pubmed-author:RiceAA | lld:pubmed |
| pubmed-article:7534710 | pubmed:author | pubmed-author:LacombeFF | lld:pubmed |
| pubmed-article:7534710 | pubmed:author | pubmed-author:DupouxJJ | lld:pubmed |
| pubmed-article:7534710 | pubmed:author | pubmed-author:DumainPP | lld:pubmed |
| pubmed-article:7534710 | pubmed:author | pubmed-author:Dubosc-Marche... | lld:pubmed |
| pubmed-article:7534710 | pubmed:author | pubmed-author:BoironJ MJM | lld:pubmed |
| pubmed-article:7534710 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7534710 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:7534710 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7534710 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7534710 | pubmed:pagination | 303-8 | lld:pubmed |
| pubmed-article:7534710 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7534710 | pubmed:meshHeading | pubmed-meshheading:7534710-... | lld:pubmed |
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| pubmed-article:7534710 | pubmed:meshHeading | pubmed-meshheading:7534710-... | lld:pubmed |
| pubmed-article:7534710 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7534710 | pubmed:articleTitle | Cytokine-mediated expansion of 5-FU-resistant peripheral blood stem cells. | lld:pubmed |
| pubmed-article:7534710 | pubmed:affiliation | Laboratoire de Greffe de Moelle, Université de Bordeaux II, France. | lld:pubmed |
| pubmed-article:7534710 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7534710 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7534710 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7534710 | lld:pubmed |
